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Role of BH3-Only Molecules Bim and Puma in β-Cell Death in Pdx1 Deficiency

Mutations in pancreatic duodenal homeobox-1 (PDX1) are associated with diabetes in humans. Pdx1-haploinsufficient mice develop diabetes due to an increase in β-cell death leading to reduced β-cell mass. For definition of the molecular link between Pdx1 deficiency and β-cell death, Pdx1-haploinsuffic...

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Detalles Bibliográficos
Autores principales:	Ren, Decheng, Sun, Juan, Wang, Changzheng, Ye, Honggang, Mao, Liqun, Cheng, Emily H., Bell, Graeme I., Polonsky, Kenneth S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113059/ https://www.ncbi.nlm.nih.gov/pubmed/24658302 http://dx.doi.org/10.2337/db13-1513

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