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Akt-Dependent Phosphorylation of Hepatic FoxO1 Is Compartmentalized on a WD40/ProF Scaffold and Is Selectively Inhibited by aPKC in Early Phases of Diet-Induced Obesity

Initiating mechanisms that impair gluconeogenic enzymes and spare lipogenic enzymes in diet-induced obesity (DIO) are obscure. Here, we examined insulin signaling to Akt and atypical protein kinase C (aPKC) in liver and muscle and hepatic enzyme expression in mice consuming a moderate high-fat (HF)...

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Detalles Bibliográficos
Autores principales:	Sajan, Mini P., Acevedo-Duncan, Mildred E., Standaert, Mary L., Ivey, Robert A., Lee, Mackenzie, Farese, Robert V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113067/ https://www.ncbi.nlm.nih.gov/pubmed/24705403 http://dx.doi.org/10.2337/db13-1863

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