Cargando…

Glucagon-Like Peptide 1 Recruits Muscle Microvasculature and Improves Insulin’s Metabolic Action in the Presence of Insulin Resistance

Glucagon-like peptide 1 (GLP-1) acutely recruits muscle microvasculature, increases muscle delivery of insulin, and enhances muscle use of glucose, independent of its effect on insulin secretion. To examine whether GLP-1 modulates muscle microvascular and metabolic insulin responses in the setting o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chai, Weidong, Zhang, Xingxing, Barrett, Eugene J., Liu, Zhenqi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Pathophysiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113068/ https://www.ncbi.nlm.nih.gov/pubmed/24658303 http://dx.doi.org/10.2337/db13-1597

Ejemplares similares

Glucagon-Like Peptide 1 Recruits Microvasculature and Increases Glucose Use in Muscle via a Nitric Oxide–Dependent Mechanism
por: Chai, Weidong, et al.
Publicado: (2012)

Angiotensin II Receptors Modulate Muscle Microvascular and Metabolic Responses to Insulin In Vivo
por: Chai, Weidong, et al.
Publicado: (2011)

The Glucagonostatic and Insulinotropic Effects of Glucagon-Like Peptide 1 Contribute Equally to Its Glucose-Lowering Action
por: Hare, Kristine J., et al.
Publicado: (2010)

Loss of Inverse Relationship Between Pulsatile Insulin and Glucagon Secretion in Patients With Type 2 Diabetes
por: Menge, Björn A., et al.
Publicado: (2011)

Rapid Tachyphylaxis of the Glucagon-Like Peptide 1–Induced Deceleration of Gastric Emptying in Humans
por: Nauck, Michael A., et al.
Publicado: (2011)

Evidence Against an Important Role of Plasma Insulin and Glucagon Concentrations in the Increase in EGP Caused by SGLT2 Inhibitors
por: Alatrach, Mariam, et al.
Publicado: (2020)

Protein Engineering Strategies for Sustained Glucagon-Like Peptide-1 Receptor–Dependent Control of Glucose Homeostasis
por: Picha, Kristen M., et al.
Publicado: (2008)

Endothelial Fcγ Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice
por: Tanigaki, Keiji, et al.
Publicado: (2016)

GLP-1 and Insulin Recruit Muscle Microvasculature and Dilate Conduit Artery Individually But Not Additively in Healthy Humans
por: Tan, Alvin W.K., et al.
Publicado: (2018)

Preserved glucagon-like peptide-1 responses to oral glucose, but reduced incretin effect, insulin secretion and sensitivity in young Asians with type 2 diabetes mellitus
por: Yeow, Toh Peng, et al.
Publicado: (2017)

The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium
por: Abbas, Afroze, et al.
Publicado: (2011)

Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia
por: Diggs-Andrews, Kelly A., et al.
Publicado: (2010)

Glucagon-Like Peptide 1 Receptor Activation Augments Cardiac Output and Improves Cardiac Efficiency in Obese Swine After Myocardial Infarction
por: Sassoon, Daniel J., et al.
Publicado: (2017)

Muscle-Specific Vascular Endothelial Growth Factor Deletion Induces Muscle Capillary Rarefaction Creating Muscle Insulin Resistance
por: Bonner, Jeffrey S., et al.
Publicado: (2013)

Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans
por: Badin, Pierre-Marie, et al.
Publicado: (2011)

Muscle Insulin Resistance and the Inflamed Microvasculature: Fire from Within
por: Liu, Jia, et al.
Publicado: (2019)

Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance: Another Paradox in Endurance-Trained Athletes?
por: Amati, Francesca, et al.
Publicado: (2011)

Perivascular Adipose Tissue Control of Insulin-Induced Vasoreactivity in Muscle Is Impaired in db/db Mice
por: Meijer, Rick I., et al.
Publicado: (2013)

IGF-I Bioactivity in an Elderly Population: Relation to Insulin Sensitivity, Insulin Levels, and the Metabolic Syndrome
por: Brugts, Michael P., et al.
Publicado: (2010)

Regulation of Mitochondrial Biogenesis by Lipoprotein Lipase in Muscle of Insulin-Resistant Offspring of Parents With Type 2 Diabetes
por: Morino, Katsutaro, et al.
Publicado: (2012)

Skeletal Muscle TRIB3 Mediates Glucose Toxicity in Diabetes and High- Fat Diet–Induced Insulin Resistance
por: Zhang, Wei, et al.
Publicado: (2016)

Insulin-Like Growth Factor Axis and Gestational Diabetes Mellitus: A Longitudinal Study in a Multiracial Cohort
por: Zhu, Yeyi, et al.
Publicado: (2016)

Developmental Programming by Maternal Insulin Resistance: Hyperinsulinemia, Glucose Intolerance, and Dysregulated Lipid Metabolism in Male Offspring of Insulin-Resistant Mice
por: Isganaitis, Elvira, et al.
Publicado: (2014)

CD14 Modulates Inflammation-Driven Insulin Resistance
por: Fernández-Real, José Manuel, et al.
Publicado: (2011)

Acute Modulation of Toll-Like Receptors by Insulin
por: Ghanim, Husam, et al.
Publicado: (2008)

Effect of Salsalate on Insulin Action, Secretion, and Clearance in Nondiabetic, Insulin-Resistant Individuals: A Randomized, Placebo-Controlled Study
por: Kim, Sun H., et al.
Publicado: (2014)

Too Much Glucagon, Too Little Insulin: Time course of pancreatic islet dysfunction in new-onset type 1 diabetes
por: Brown, Rebecca J., et al.
Publicado: (2008)

Effect of Endothelium-Specific Insulin Resistance on Endothelial Function In Vivo
por: Duncan, Edward R., et al.
Publicado: (2008)

Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver
por: Jelenik, Tomas, et al.
Publicado: (2017)

Increased Lipolysis, Diminished Adipose Tissue Insulin Sensitivity, and Impaired β-Cell Function Relative to Adipose Tissue Insulin Sensitivity in Obese Youth With Impaired Glucose Tolerance
por: Kim, Joon Young, et al.
Publicado: (2017)

Interactions Among Glucose Delivery, Transport, and Phosphorylation That Underlie Skeletal Muscle Insulin Resistance in Obesity and Type 2 Diabetes: Studies With Dynamic PET Imaging
por: Goodpaster, Bret H., et al.
Publicado: (2014)

Genetic Defects in Human Pericentrin Are Associated With Severe Insulin Resistance and Diabetes
por: Huang-Doran, Isabel, et al.
Publicado: (2011)

FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction
por: Bravard, Amélie, et al.
Publicado: (2011)

Glucagon-like peptide-1 receptor agonists are not associated with retinal adverse events in the FDA Adverse Event Reporting System
por: Fadini, Gian Paolo, et al.
Publicado: (2018)

Effects of Rosiglitazone, Glyburide, and Metformin on β-Cell Function and Insulin Sensitivity in ADOPT
por: Kahn, Steven E., et al.
Publicado: (2011)

Adaptation of β-Cell and Endothelial Function to Carbohydrate Loading: Influence of Insulin Resistance
por: Hurwitz, Barry E., et al.
Publicado: (2015)

Renal Denervation Reverses Hepatic Insulin Resistance Induced by High-Fat Diet
por: Iyer, Malini S., et al.
Publicado: (2016)

Expression of Human Chemerin Induces Insulin Resistance in the Skeletal Muscle but Does Not Affect Weight, Lipid Levels, and Atherosclerosis in LDL Receptor Knockout Mice on High-Fat Diet
por: Becker, Melanie, et al.
Publicado: (2010)

Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy
por: Eller, Kathrin, et al.
Publicado: (2011)

Age-Related Impairment in Insulin Release: The Essential Role of β(2)-Adrenergic Receptor
por: Santulli, Gaetano, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_sregf537nnn240em1ii7n4456o