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Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions
The prevalence of diabetes increases with age, driven in part by an absolute increase in incidence among adults aged 65 years and older. Individuals with diabetes are at higher risk for cardiovascular disease, and age strongly predicts cardiovascular complications. Inflammation and oxidative stress...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113072/ https://www.ncbi.nlm.nih.gov/pubmed/25060886 http://dx.doi.org/10.2337/db14-0020 |
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author | Halter, Jeffrey B. Musi, Nicolas McFarland Horne, Frances Crandall, Jill P. Goldberg, Andrew Harkless, Lawrence Hazzard, William R. Huang, Elbert S. Kirkman, M. Sue Plutzky, Jorge Schmader, Kenneth E. Zieman, Susan High, Kevin P. |
author_facet | Halter, Jeffrey B. Musi, Nicolas McFarland Horne, Frances Crandall, Jill P. Goldberg, Andrew Harkless, Lawrence Hazzard, William R. Huang, Elbert S. Kirkman, M. Sue Plutzky, Jorge Schmader, Kenneth E. Zieman, Susan High, Kevin P. |
author_sort | Halter, Jeffrey B. |
collection | PubMed |
description | The prevalence of diabetes increases with age, driven in part by an absolute increase in incidence among adults aged 65 years and older. Individuals with diabetes are at higher risk for cardiovascular disease, and age strongly predicts cardiovascular complications. Inflammation and oxidative stress appear to play some role in the mechanisms underlying aging, diabetes, cardiovascular disease, and other complications of diabetes. However, the mechanisms underlying the age-associated increase in risk for diabetes and diabetes-related cardiovascular disease remain poorly understood. Moreover, because of the heterogeneity of the older population, a lack of understanding of the biology of aging, and inadequate study of the effects of treatments on traditional complications and geriatric conditions associated with diabetes, no consensus exists on the optimal interventions for older diabetic adults. The Association of Specialty Professors, along with the National Institute on Aging, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Heart, Lung, and Blood Institute, and the American Diabetes Association, held a workshop, summarized in this Perspective, to discuss current knowledge regarding diabetes and cardiovascular disease in older adults, identify gaps, and propose questions to guide future research. |
format | Online Article Text |
id | pubmed-4113072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-41130722015-08-01 Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions Halter, Jeffrey B. Musi, Nicolas McFarland Horne, Frances Crandall, Jill P. Goldberg, Andrew Harkless, Lawrence Hazzard, William R. Huang, Elbert S. Kirkman, M. Sue Plutzky, Jorge Schmader, Kenneth E. Zieman, Susan High, Kevin P. Diabetes Perspectives in Diabetes The prevalence of diabetes increases with age, driven in part by an absolute increase in incidence among adults aged 65 years and older. Individuals with diabetes are at higher risk for cardiovascular disease, and age strongly predicts cardiovascular complications. Inflammation and oxidative stress appear to play some role in the mechanisms underlying aging, diabetes, cardiovascular disease, and other complications of diabetes. However, the mechanisms underlying the age-associated increase in risk for diabetes and diabetes-related cardiovascular disease remain poorly understood. Moreover, because of the heterogeneity of the older population, a lack of understanding of the biology of aging, and inadequate study of the effects of treatments on traditional complications and geriatric conditions associated with diabetes, no consensus exists on the optimal interventions for older diabetic adults. The Association of Specialty Professors, along with the National Institute on Aging, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Heart, Lung, and Blood Institute, and the American Diabetes Association, held a workshop, summarized in this Perspective, to discuss current knowledge regarding diabetes and cardiovascular disease in older adults, identify gaps, and propose questions to guide future research. American Diabetes Association 2014-08 2014-07-17 /pmc/articles/PMC4113072/ /pubmed/25060886 http://dx.doi.org/10.2337/db14-0020 Text en © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. |
spellingShingle | Perspectives in Diabetes Halter, Jeffrey B. Musi, Nicolas McFarland Horne, Frances Crandall, Jill P. Goldberg, Andrew Harkless, Lawrence Hazzard, William R. Huang, Elbert S. Kirkman, M. Sue Plutzky, Jorge Schmader, Kenneth E. Zieman, Susan High, Kevin P. Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions |
title | Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions |
title_full | Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions |
title_fullStr | Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions |
title_full_unstemmed | Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions |
title_short | Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions |
title_sort | diabetes and cardiovascular disease in older adults: current status and future directions |
topic | Perspectives in Diabetes |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113072/ https://www.ncbi.nlm.nih.gov/pubmed/25060886 http://dx.doi.org/10.2337/db14-0020 |
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