Cargando…

IRAK-M Deficiency Promotes the Development of Type 1 Diabetes in NOD Mice

Type 1 diabetes mellitus (T1DM) is an organ-specific autoimmune disease characterized by progressive destruction of insulin-secreting pancreatic β-cells. Both T-cell–mediated adaptive responses as well as innate immune processes are involved in pathogenesis. Interleukin-1 receptor–associated kinase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tan, Qiyuan, Majewska-Szczepanik, Monika, Zhang, Xiaojun, Szczepanik, Marian, Zhou, Zhiguang, Wong, F. Susan, Wen, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113073/ https://www.ncbi.nlm.nih.gov/pubmed/24696448 http://dx.doi.org/10.2337/db13-1504

Ejemplares similares

Insulin-Reactive T Cells Convert Diabetogenic Insulin-Reactive VH125 B Cells Into Tolerogenic Cells by Reducing Germinal Center T:B Cell Interactions in NOD Mice
por: Pearson, James A., et al.
Publicado: (2020)

Deficiency of Nuclear Factor-κB c-Rel Accelerates the Development of Autoimmune Diabetes in NOD Mice
por: Ramakrishnan, Parameswaran, et al.
Publicado: (2016)

Adoptive Transfer of Immunomodulatory M2 Macrophages Prevents Type 1 Diabetes in NOD Mice
por: Parsa, Roham, et al.
Publicado: (2012)

Ganglioside GM1 Deficiency in Effector T Cells From NOD Mice Induces Resistance to Regulatory T-Cell Suppression
por: Wu, Gusheng, et al.
Publicado: (2011)

Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice
por: Sodré, Fernanda M.C., et al.
Publicado: (2021)

Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes
por: Xue, Song, et al.
Publicado: (2015)

A Novel Clinically Relevant Strategy to Abrogate Autoimmunity and Regulate Alloimmunity in NOD Mice
por: Vergani, Andrea, et al.
Publicado: (2010)

Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability
por: Thirawatananond, Puchong, et al.
Publicado: (2023)

Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice
por: Mangada, Julie, et al.
Publicado: (2009)

IL-13Rα1 Expression on β-Cell–Specific T Cells in NOD Mice
por: Rasche, Sarah S., et al.
Publicado: (2011)

Prevention of Autoimmune Diabetes and Induction of β-Cell Proliferation in NOD Mice by Hyperbaric Oxygen Therapy
por: Faleo, Gaetano, et al.
Publicado: (2012)

Inflammatory Tendencies and Overproduction of IL-17 in the Colon of Young NOD Mice Are Counteracted With Diet Change
por: Alam, Catharina, et al.
Publicado: (2010)

Coxsackievirus B Vaccines Prevent Infection-Accelerated Diabetes in NOD Mice and Have No Disease-Inducing Effect
por: Stone, Virginia M., et al.
Publicado: (2021)

Plasmacytoid Precursor Dendritic Cells From NOD Mice Exhibit Impaired Function : Are They a Component of Diabetes Pathogenesis?
por: Huang, Yiming, et al.
Publicado: (2008)

ZnT8-Reactive T Cells Are Weakly Pathogenic in NOD Mice but Can Participate in Diabetes Under Inflammatory Conditions
por: Nayak, Deepak K., et al.
Publicado: (2014)

Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes
por: Mathews, Clayton E., et al.
Publicado: (2015)

Idd9/11 Genetic Locus Regulates Diabetogenic Activity of CD4 T-Cells in Nonobese Diabetic (NOD) Mice
por: Chen, Yi-Guang, et al.
Publicado: (2008)

Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice
por: Nakayama, Maki, et al.
Publicado: (2012)

Long-Term Remission of Diabetes in NOD Mice Is Induced by Nondepleting Anti-CD4 and Anti-CD8 Antibodies
por: Yi, Zuoan, et al.
Publicado: (2012)

Immunoglobulin-Like Transcript 3-Fc Suppresses T-Cell Responses to Allogeneic Human Islet Transplants in hu-NOD/SCID Mice
por: Vlad, George, et al.
Publicado: (2008)

Following the Fate of One Insulin-Reactive CD4 T cell: Conversion Into Teffs and Tregs in the Periphery Controls Diabetes in NOD Mice
por: Fousteri, Georgia, et al.
Publicado: (2012)

Prevention of “Humanized” Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach
por: Niens, Marijke, et al.
Publicado: (2011)

IL-10 Deficiency Accelerates Type 1 Diabetes Development via Modulation of Innate and Adaptive Immune Cells and Gut Microbiota in BDC2.5 NOD Mice
por: Huang, Juan, et al.
Publicado: (2021)

Extracellular High-Mobility Group Box 1 Acts as an Innate Immune Mediator to Enhance Autoimmune Progression and Diabetes Onset in NOD Mice
por: Han, Junyan, et al.
Publicado: (2008)

Dipeptidyl Peptidase IV Inhibition With MK0431 Improves Islet Graft Survival in Diabetic NOD Mice Partially via T-Cell Modulation
por: Kim, Su-Jin, et al.
Publicado: (2009)

Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade: Evidence of Improved Immune Regulation
por: Ablamunits, Vitaly, et al.
Publicado: (2012)

Thymic Stromal Lymphopoietin and Thymic Stromal Lymphopoietin–Conditioned Dendritic Cells Induce Regulatory T-Cell Differentiation and Protection of NOD Mice Against Diabetes
por: Besin, Gilles, et al.
Publicado: (2008)

Induction of Mixed Chimerism With MHC-Mismatched but Not Matched Bone Marrow Transplants Results in Thymic Deletion of Host-Type Autoreactive T-Cells in NOD Mice
por: Racine, Jeremy, et al.
Publicado: (2011)

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells
por: Krishnamurthy, Balasubramanian, et al.
Publicado: (2012)

Glucose and Inflammation Control Islet Vascular Density and β-Cell Function in NOD Mice: Control of Islet Vasculature and Vascular Endothelial Growth Factor by Glucose
por: Akirav, Eitan M., et al.
Publicado: (2011)

B-Lymphocytes Expressing an Ig Specificity Recognizing the Pancreatic β-Cell Autoantigen Peripherin Are Potent Contributors to Type 1 Diabetes Development in NOD Mice
por: Leeth, Caroline M., et al.
Publicado: (2016)

A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice
por: Gill, Ronald G., et al.
Publicado: (2016)

Deletion of the G6pc2 Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice
por: Oeser, James K., et al.
Publicado: (2011)

Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1(null) IL2rγ(null) Ins2(Akita) Mice
por: Brehm, Michael A., et al.
Publicado: (2010)

PTPN22 Silencing in the NOD Model Indicates the Type 1 Diabetes–Associated Allele Is Not a Loss-of-Function Variant
por: Zheng, Peilin, et al.
Publicado: (2013)

Unexpected Acceleration of Type 1 Diabetes by Transgenic Expression of B7-H1 in NOD Mouse Peri-Islet Glia
por: Yantha, Jason, et al.
Publicado: (2010)

TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis
por: Liu, Lunhua, et al.
Publicado: (2018)

HLA-A2–Matched Peripheral Blood Mononuclear Cells From Type 1 Diabetic Patients, but Not Nondiabetic Donors, Transfer Insulitis to NOD-scid/γc(null)/HLA-A2 Transgenic Mice Concurrent With the Expansion of Islet-Specific CD8(+) T cells
por: Whitfield-Larry, Fatima, et al.
Publicado: (2011)

Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes
por: Martin, Andrea P., et al.
Publicado: (2008)

NLRP6 deficiency expands a novel CD103(+) B cell population that confers immune tolerance in NOD mice
por: Pearson, James A., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_nauq2niv95jsg4on9uhasktdpv