When fate follows age: unequal centrosomes in asymmetric cell division

A strong correlation between centrosome age and fate has been reported in some stem cells and progenitors that divide asymmetrically. In some cases, such stereotyped centrosome behaviour is essential to endow stemness to only one of the two daughters, whereas in other cases causality is still uncert...

Descripción completa

Detalles Bibliográficos
Autores principales: Reina, Jose, Gonzalez, Cayetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2014
Materias:
Part IV: Centrosomes in development and disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113110/
https://www.ncbi.nlm.nih.gov/pubmed/25047620
http://dx.doi.org/10.1098/rstb.2013.0466
_version_ 1782328245981544448
author Reina, Jose
Gonzalez, Cayetano
author_facet Reina, Jose
Gonzalez, Cayetano
author_sort Reina, Jose
collection PubMed
description A strong correlation between centrosome age and fate has been reported in some stem cells and progenitors that divide asymmetrically. In some cases, such stereotyped centrosome behaviour is essential to endow stemness to only one of the two daughters, whereas in other cases causality is still uncertain. Here, we present the different cell types in which correlated centrosome age and fate has been documented, review current knowledge on the underlying molecular mechanisms and discuss possible functional implications of this process.
format Online
Article
Text
id pubmed-4113110
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher The Royal Society
record_format MEDLINE/PubMed
spelling pubmed-41131102014-09-05 When fate follows age: unequal centrosomes in asymmetric cell division Reina, Jose Gonzalez, Cayetano Philos Trans R Soc Lond B Biol Sci Part IV: Centrosomes in development and disease A strong correlation between centrosome age and fate has been reported in some stem cells and progenitors that divide asymmetrically. In some cases, such stereotyped centrosome behaviour is essential to endow stemness to only one of the two daughters, whereas in other cases causality is still uncertain. Here, we present the different cell types in which correlated centrosome age and fate has been documented, review current knowledge on the underlying molecular mechanisms and discuss possible functional implications of this process. The Royal Society 2014-09-05 /pmc/articles/PMC4113110/ /pubmed/25047620 http://dx.doi.org/10.1098/rstb.2013.0466 Text en http://creativecommons.org/licenses/by/3.0/ © 2014 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Part IV: Centrosomes in development and disease
Reina, Jose
Gonzalez, Cayetano
When fate follows age: unequal centrosomes in asymmetric cell division
title When fate follows age: unequal centrosomes in asymmetric cell division
title_full When fate follows age: unequal centrosomes in asymmetric cell division
title_fullStr When fate follows age: unequal centrosomes in asymmetric cell division
title_full_unstemmed When fate follows age: unequal centrosomes in asymmetric cell division
title_short When fate follows age: unequal centrosomes in asymmetric cell division
title_sort when fate follows age: unequal centrosomes in asymmetric cell division
topic Part IV: Centrosomes in development and disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113110/
https://www.ncbi.nlm.nih.gov/pubmed/25047620
http://dx.doi.org/10.1098/rstb.2013.0466
work_keys_str_mv AT reinajose whenfatefollowsageunequalcentrosomesinasymmetriccelldivision
AT gonzalezcayetano whenfatefollowsageunequalcentrosomesinasymmetriccelldivision

Ejemplares similares