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Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation

BACKGROUND: Constipation is a frequent complaint and the combination of a prebiotic and probiotics could have a potentially synergic effect on the intestinal transit. The present study therefore aims to investigate the combination of polydextrose (Litesse®), L. acidophilus NCFM® and B. lactis HN019...

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Autores principales: Magro, Daniéla Oliveira, de Oliveira, Lais Mariana R, Bernasconi, Isabela, Ruela, Marilia de Souza, Credidio, Laura, Barcelos, Irene K, Leal, Raquel F, Ayrizono, Maria de Lourdes Stesuko, Fagundes, João José, Teixeira, Leandro de B, Ouwehand, Arthur C, Coy, Claudio S R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113128/
https://www.ncbi.nlm.nih.gov/pubmed/25056655
http://dx.doi.org/10.1186/1475-2891-13-75
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author Magro, Daniéla Oliveira
de Oliveira, Lais Mariana R
Bernasconi, Isabela
Ruela, Marilia de Souza
Credidio, Laura
Barcelos, Irene K
Leal, Raquel F
Ayrizono, Maria de Lourdes Stesuko
Fagundes, João José
Teixeira, Leandro de B
Ouwehand, Arthur C
Coy, Claudio S R
author_facet Magro, Daniéla Oliveira
de Oliveira, Lais Mariana R
Bernasconi, Isabela
Ruela, Marilia de Souza
Credidio, Laura
Barcelos, Irene K
Leal, Raquel F
Ayrizono, Maria de Lourdes Stesuko
Fagundes, João José
Teixeira, Leandro de B
Ouwehand, Arthur C
Coy, Claudio S R
author_sort Magro, Daniéla Oliveira
collection PubMed
description BACKGROUND: Constipation is a frequent complaint and the combination of a prebiotic and probiotics could have a potentially synergic effect on the intestinal transit. The present study therefore aims to investigate the combination of polydextrose (Litesse®), L. acidophilus NCFM® and B. lactis HN019 in a yogurt on intestinal transit in subjects who suffer from constipation. METHODS: Patients with constipation were randomly divided into two groups, Control Group (CG) and Treatment Group (TG), and had to eat 180 ml of unflavored yogurt every morning for 14 days. Those in the CG received only yogurt, while the TG received yogurt containing polydextrose, L. acidophilus NCFM® (ATCC 700396) and B. lactis HN019 (AGAL NM97/09513). RESULTS: Favourable clinical response was assessed since Agachan score had a significant reduction at the end of the study in both groups and tended to be better in the TG. The subjects in the treatment group also had a shorter transit time at the end of the intervention compared to the control group (p = 0.01). CONCLUSION: The product containing yogurt with polydextrose, B. lactis HN019 and L. acidophilus NCFM® significantly shortened colonic transit time after two weeks in the TG compared to CG and may be an option for treatment of constipation.
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spelling pubmed-41131282014-07-29 Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation Magro, Daniéla Oliveira de Oliveira, Lais Mariana R Bernasconi, Isabela Ruela, Marilia de Souza Credidio, Laura Barcelos, Irene K Leal, Raquel F Ayrizono, Maria de Lourdes Stesuko Fagundes, João José Teixeira, Leandro de B Ouwehand, Arthur C Coy, Claudio S R Nutr J Research BACKGROUND: Constipation is a frequent complaint and the combination of a prebiotic and probiotics could have a potentially synergic effect on the intestinal transit. The present study therefore aims to investigate the combination of polydextrose (Litesse®), L. acidophilus NCFM® and B. lactis HN019 in a yogurt on intestinal transit in subjects who suffer from constipation. METHODS: Patients with constipation were randomly divided into two groups, Control Group (CG) and Treatment Group (TG), and had to eat 180 ml of unflavored yogurt every morning for 14 days. Those in the CG received only yogurt, while the TG received yogurt containing polydextrose, L. acidophilus NCFM® (ATCC 700396) and B. lactis HN019 (AGAL NM97/09513). RESULTS: Favourable clinical response was assessed since Agachan score had a significant reduction at the end of the study in both groups and tended to be better in the TG. The subjects in the treatment group also had a shorter transit time at the end of the intervention compared to the control group (p = 0.01). CONCLUSION: The product containing yogurt with polydextrose, B. lactis HN019 and L. acidophilus NCFM® significantly shortened colonic transit time after two weeks in the TG compared to CG and may be an option for treatment of constipation. BioMed Central 2014-07-24 /pmc/articles/PMC4113128/ /pubmed/25056655 http://dx.doi.org/10.1186/1475-2891-13-75 Text en Copyright © 2014 Magro et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Magro, Daniéla Oliveira
de Oliveira, Lais Mariana R
Bernasconi, Isabela
Ruela, Marilia de Souza
Credidio, Laura
Barcelos, Irene K
Leal, Raquel F
Ayrizono, Maria de Lourdes Stesuko
Fagundes, João José
Teixeira, Leandro de B
Ouwehand, Arthur C
Coy, Claudio S R
Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation
title Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation
title_full Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation
title_fullStr Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation
title_full_unstemmed Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation
title_short Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation
title_sort effect of yogurt containing polydextrose, lactobacillus acidophilus ncfm and bifidobacterium lactis hn019: a randomized, double-blind, controlled study in chronic constipation
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113128/
https://www.ncbi.nlm.nih.gov/pubmed/25056655
http://dx.doi.org/10.1186/1475-2891-13-75
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