Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer

The downstream targets of hypoxia inducible factor-1 alpha (HIF-1α) play an important role in tumor progression and angiogenesis. Therefore, inhibition of HIF-mediated transcription has potential in the treatment of cancer. One attractive strategy for inhibiting HIF activity is the disruption of the...

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Detalles Bibliográficos
Autores principales: Reece, Kelie M, Richardson, Emily D, Cook, Kristina M, Campbell, Tessa J, Pisle, Stephen T, Holly, Alesia J, Venzon, David J, Liewehr, David J, Chau, Cindy H, Price, Douglas K, Figg, William D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113146/
https://www.ncbi.nlm.nih.gov/pubmed/24775564
http://dx.doi.org/10.1186/1476-4598-13-91

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113146/
https://www.ncbi.nlm.nih.gov/pubmed/24775564
http://dx.doi.org/10.1186/1476-4598-13-91

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