Carbamoylating Activity Associated with the Activation of the Antitumor Agent Laromustine Inhibits Angiogenesis by Inducing ASK1-Dependent Endothelial Cell Death

The anticancer agent 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (laromustine), upon decomposition in situ, yields methyl isocyanate and the chloroethylating species 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine (90CE). 90CE has been shown to kill tumor cells vi...

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Detalles Bibliográficos
Autores principales: Ji, Weidong, Yang, Mei, Praggastis, Alexandra, Li, Yonghao, Zhou, Huanjiao Jenny, He, Yun, Ghazvinian, Roxanne, Cincotta, Dylan J., Rice, Kevin P., Min, Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113355/
https://www.ncbi.nlm.nih.gov/pubmed/25068797
http://dx.doi.org/10.1371/journal.pone.0103224

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