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Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors

Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the developing nervous system, but have been recently evidenced as also playing a role in the immune system. Here we describe the expression and role of semaphorin 3F (SEMA3F) and its receptor ne...

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Autores principales: Mendes-da-Cruz, Daniella Arêas, Brignier, Anne Colette, Asnafi, Vahid, Baleydier, Frederic, Messias, Carolina Valença, Lepelletier, Yves, Bedjaoui, Nawel, Renand, Amedée, Smaniotto, Salete, Canioni, Danielle, Milpied, Pierre, Balabanian, Karl, Bousso, Philippe, Leprêtre, Stéphane, Bertrand, Yves, Dombret, Hervé, Ifrah, Norbert, Dardenne, Mireille, Macintyre, Elizabeth, Savino, Wilson, Hermine, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113369/
https://www.ncbi.nlm.nih.gov/pubmed/25068647
http://dx.doi.org/10.1371/journal.pone.0103405
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author Mendes-da-Cruz, Daniella Arêas
Brignier, Anne Colette
Asnafi, Vahid
Baleydier, Frederic
Messias, Carolina Valença
Lepelletier, Yves
Bedjaoui, Nawel
Renand, Amedée
Smaniotto, Salete
Canioni, Danielle
Milpied, Pierre
Balabanian, Karl
Bousso, Philippe
Leprêtre, Stéphane
Bertrand, Yves
Dombret, Hervé
Ifrah, Norbert
Dardenne, Mireille
Macintyre, Elizabeth
Savino, Wilson
Hermine, Olivier
author_facet Mendes-da-Cruz, Daniella Arêas
Brignier, Anne Colette
Asnafi, Vahid
Baleydier, Frederic
Messias, Carolina Valença
Lepelletier, Yves
Bedjaoui, Nawel
Renand, Amedée
Smaniotto, Salete
Canioni, Danielle
Milpied, Pierre
Balabanian, Karl
Bousso, Philippe
Leprêtre, Stéphane
Bertrand, Yves
Dombret, Hervé
Ifrah, Norbert
Dardenne, Mireille
Macintyre, Elizabeth
Savino, Wilson
Hermine, Olivier
author_sort Mendes-da-Cruz, Daniella Arêas
collection PubMed
description Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the developing nervous system, but have been recently evidenced as also playing a role in the immune system. Here we describe the expression and role of semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2) in human T cell precursors. NRP2 and SEMA3F are expressed in the human thymus, in both lymphoid and non-lymphoid compartments. SEMA3F have a repulsive effect on thymocyte migration and inhibited CXCL12- and sphingosine-1-phosphate (S1P)-induced thymocyte migration by inhibiting cytoskeleton reorganization prior to stimuli. Moreover, NRP2 and SEMA3F are expressed in human T-cell acute lymphoblastic leukemia/lymphoma primary cells. In these tumor cells, SEMA3F also blocks their migration induced by CXCL12 and S1P. Our data show that SEMA3F and NRP2 are further regulators of human thymocyte migration in physiological and pathological conditions.
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spelling pubmed-41133692014-08-04 Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors Mendes-da-Cruz, Daniella Arêas Brignier, Anne Colette Asnafi, Vahid Baleydier, Frederic Messias, Carolina Valença Lepelletier, Yves Bedjaoui, Nawel Renand, Amedée Smaniotto, Salete Canioni, Danielle Milpied, Pierre Balabanian, Karl Bousso, Philippe Leprêtre, Stéphane Bertrand, Yves Dombret, Hervé Ifrah, Norbert Dardenne, Mireille Macintyre, Elizabeth Savino, Wilson Hermine, Olivier PLoS One Research Article Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the developing nervous system, but have been recently evidenced as also playing a role in the immune system. Here we describe the expression and role of semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2) in human T cell precursors. NRP2 and SEMA3F are expressed in the human thymus, in both lymphoid and non-lymphoid compartments. SEMA3F have a repulsive effect on thymocyte migration and inhibited CXCL12- and sphingosine-1-phosphate (S1P)-induced thymocyte migration by inhibiting cytoskeleton reorganization prior to stimuli. Moreover, NRP2 and SEMA3F are expressed in human T-cell acute lymphoblastic leukemia/lymphoma primary cells. In these tumor cells, SEMA3F also blocks their migration induced by CXCL12 and S1P. Our data show that SEMA3F and NRP2 are further regulators of human thymocyte migration in physiological and pathological conditions. Public Library of Science 2014-07-28 /pmc/articles/PMC4113369/ /pubmed/25068647 http://dx.doi.org/10.1371/journal.pone.0103405 Text en © 2014 Mendes-da-Cruz et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Mendes-da-Cruz, Daniella Arêas
Brignier, Anne Colette
Asnafi, Vahid
Baleydier, Frederic
Messias, Carolina Valença
Lepelletier, Yves
Bedjaoui, Nawel
Renand, Amedée
Smaniotto, Salete
Canioni, Danielle
Milpied, Pierre
Balabanian, Karl
Bousso, Philippe
Leprêtre, Stéphane
Bertrand, Yves
Dombret, Hervé
Ifrah, Norbert
Dardenne, Mireille
Macintyre, Elizabeth
Savino, Wilson
Hermine, Olivier
Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors
title Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors
title_full Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors
title_fullStr Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors
title_full_unstemmed Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors
title_short Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors
title_sort semaphorin 3f and neuropilin-2 control the migration of human t-cell precursors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113369/
https://www.ncbi.nlm.nih.gov/pubmed/25068647
http://dx.doi.org/10.1371/journal.pone.0103405
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