Blocking Phosphatidylcholine Utilization in Pseudomonas aeruginosa, via Mutagenesis of Fatty Acid, Glycerol and Choline Degradation Pathways, Confirms the Importance of This Nutrient Source In Vivo

Pseudomonas aeruginosa can grow to very high-cell-density (HCD) during infection of the cystic fibrosis (CF) lung. Phosphatidylcholine (PC), the major component of lung surfactant, has been hypothesized to support HCD growth of P. aeruginosa in vivo. The phosphorylcholine headgroup, a glycerol molec...

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Detalles Bibliográficos
Autores principales: Sun, Zhenxin, Kang, Yun, Norris, Michael H., Troyer, Ryan M., Son, Mike S., Schweizer, Herbert P., Dow, Steven W., Hoang, Tung T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113454/
https://www.ncbi.nlm.nih.gov/pubmed/25068317
http://dx.doi.org/10.1371/journal.pone.0103778

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