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Characterization of the Prostate-Specific Antigen (PSA) Catalytic Mechanism: A Pre-Steady-State and Steady-State Study
Prostate-specific antigen (PSA), an enzyme of 30 kDa grouped in the kallikrein family is synthesized to high levels by normal and malignant prostate epithelial cells. Therefore, it is the main biomarker currently used for early diagnosis of prostate cancer. Here, presteady-state and steady-state kin...
Autores principales: | Tomao, Luigi, Sbardella, Diego, Gioia, Magda, Di Masi, Alessandra, Marini, Stefano, Ascenzi, Paolo, Coletta, Massimo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113483/ https://www.ncbi.nlm.nih.gov/pubmed/25068395 http://dx.doi.org/10.1371/journal.pone.0102470 |
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