RNA Virus Reverse Genetics and Vaccine Design

RNA viruses are capable of rapid spread and severe or potentially lethal disease in both animals and humans. The development of reverse genetics systems for manipulation and study of RNA virus genomes has provided platforms for designing and optimizing viral mutants for vaccine development. Here, we...

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Detalles Bibliográficos
Autores principales: Stobart, Christopher C., Moore, Martin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113782/
https://www.ncbi.nlm.nih.gov/pubmed/24967693
http://dx.doi.org/10.3390/v6072531
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author Stobart, Christopher C.
Moore, Martin L.
author_facet Stobart, Christopher C.
Moore, Martin L.
author_sort Stobart, Christopher C.
collection PubMed
description RNA viruses are capable of rapid spread and severe or potentially lethal disease in both animals and humans. The development of reverse genetics systems for manipulation and study of RNA virus genomes has provided platforms for designing and optimizing viral mutants for vaccine development. Here, we review the impact of RNA virus reverse genetics systems on past and current efforts to design effective and safe viral therapeutics and vaccines.
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spelling pubmed-41137822014-07-29 RNA Virus Reverse Genetics and Vaccine Design Stobart, Christopher C. Moore, Martin L. Viruses Review RNA viruses are capable of rapid spread and severe or potentially lethal disease in both animals and humans. The development of reverse genetics systems for manipulation and study of RNA virus genomes has provided platforms for designing and optimizing viral mutants for vaccine development. Here, we review the impact of RNA virus reverse genetics systems on past and current efforts to design effective and safe viral therapeutics and vaccines. MDPI 2014-06-25 /pmc/articles/PMC4113782/ /pubmed/24967693 http://dx.doi.org/10.3390/v6072531 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Stobart, Christopher C.
Moore, Martin L.
RNA Virus Reverse Genetics and Vaccine Design
title RNA Virus Reverse Genetics and Vaccine Design
title_full RNA Virus Reverse Genetics and Vaccine Design
title_fullStr RNA Virus Reverse Genetics and Vaccine Design
title_full_unstemmed RNA Virus Reverse Genetics and Vaccine Design
title_short RNA Virus Reverse Genetics and Vaccine Design
title_sort rna virus reverse genetics and vaccine design
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113782/
https://www.ncbi.nlm.nih.gov/pubmed/24967693
http://dx.doi.org/10.3390/v6072531
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