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Marine Microorganism-Invertebrate Assemblages: Perspectives to Solve the “Supply Problem” in the Initial Steps of Drug Discovery
The chemical diversity associated with marine natural products (MNP) is unanimously acknowledged as the “blue gold” in the urgent quest for new drugs. Consequently, a significant increase in the discovery of MNP published in the literature has been observed in the past decades, particularly from mar...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113807/ https://www.ncbi.nlm.nih.gov/pubmed/24983638 http://dx.doi.org/10.3390/md12073929 |
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author | Leal, Miguel Costa Sheridan, Christopher Osinga, Ronald Dionísio, Gisela Rocha, Rui Jorge Miranda Silva, Bruna Rosa, Rui Calado, Ricardo |
author_facet | Leal, Miguel Costa Sheridan, Christopher Osinga, Ronald Dionísio, Gisela Rocha, Rui Jorge Miranda Silva, Bruna Rosa, Rui Calado, Ricardo |
author_sort | Leal, Miguel Costa |
collection | PubMed |
description | The chemical diversity associated with marine natural products (MNP) is unanimously acknowledged as the “blue gold” in the urgent quest for new drugs. Consequently, a significant increase in the discovery of MNP published in the literature has been observed in the past decades, particularly from marine invertebrates. However, it remains unclear whether target metabolites originate from the marine invertebrates themselves or from their microbial symbionts. This issue underlines critical challenges associated with the lack of biomass required to supply the early stages of the drug discovery pipeline. The present review discusses potential solutions for such challenges, with particular emphasis on innovative approaches to culture invertebrate holobionts (microorganism-invertebrate assemblages) through in toto aquaculture, together with methods for the discovery and initial production of bioactive compounds from these microbial symbionts. |
format | Online Article Text |
id | pubmed-4113807 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-41138072014-07-29 Marine Microorganism-Invertebrate Assemblages: Perspectives to Solve the “Supply Problem” in the Initial Steps of Drug Discovery Leal, Miguel Costa Sheridan, Christopher Osinga, Ronald Dionísio, Gisela Rocha, Rui Jorge Miranda Silva, Bruna Rosa, Rui Calado, Ricardo Mar Drugs Review The chemical diversity associated with marine natural products (MNP) is unanimously acknowledged as the “blue gold” in the urgent quest for new drugs. Consequently, a significant increase in the discovery of MNP published in the literature has been observed in the past decades, particularly from marine invertebrates. However, it remains unclear whether target metabolites originate from the marine invertebrates themselves or from their microbial symbionts. This issue underlines critical challenges associated with the lack of biomass required to supply the early stages of the drug discovery pipeline. The present review discusses potential solutions for such challenges, with particular emphasis on innovative approaches to culture invertebrate holobionts (microorganism-invertebrate assemblages) through in toto aquaculture, together with methods for the discovery and initial production of bioactive compounds from these microbial symbionts. MDPI 2014-06-30 /pmc/articles/PMC4113807/ /pubmed/24983638 http://dx.doi.org/10.3390/md12073929 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Leal, Miguel Costa Sheridan, Christopher Osinga, Ronald Dionísio, Gisela Rocha, Rui Jorge Miranda Silva, Bruna Rosa, Rui Calado, Ricardo Marine Microorganism-Invertebrate Assemblages: Perspectives to Solve the “Supply Problem” in the Initial Steps of Drug Discovery |
title | Marine Microorganism-Invertebrate Assemblages: Perspectives to Solve the “Supply Problem” in the Initial Steps of Drug Discovery |
title_full | Marine Microorganism-Invertebrate Assemblages: Perspectives to Solve the “Supply Problem” in the Initial Steps of Drug Discovery |
title_fullStr | Marine Microorganism-Invertebrate Assemblages: Perspectives to Solve the “Supply Problem” in the Initial Steps of Drug Discovery |
title_full_unstemmed | Marine Microorganism-Invertebrate Assemblages: Perspectives to Solve the “Supply Problem” in the Initial Steps of Drug Discovery |
title_short | Marine Microorganism-Invertebrate Assemblages: Perspectives to Solve the “Supply Problem” in the Initial Steps of Drug Discovery |
title_sort | marine microorganism-invertebrate assemblages: perspectives to solve the “supply problem” in the initial steps of drug discovery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113807/ https://www.ncbi.nlm.nih.gov/pubmed/24983638 http://dx.doi.org/10.3390/md12073929 |
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