Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta

Two new indole alkaloids, hainanerectamines A (1) and B (2), and one new β-carboline alkaloids, hainanerectamines C (4), along with five known related alkaloids (3, 5–8), have been isolated from the Hainan marine sponge Hyrtios erecta. The structures of new compounds 1, 2 and 4 were determined by de...

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Detalles Bibliográficos
Autores principales: He, Wen-Fei, Xue, Duo-Qing, Yao, Li-Gong, Li, Jing-Ya, Li, Jia, Guo, Yue-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113810/
https://www.ncbi.nlm.nih.gov/pubmed/24983641
http://dx.doi.org/10.3390/md12073982
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author He, Wen-Fei
Xue, Duo-Qing
Yao, Li-Gong
Li, Jing-Ya
Li, Jia
Guo, Yue-Wei
author_facet He, Wen-Fei
Xue, Duo-Qing
Yao, Li-Gong
Li, Jing-Ya
Li, Jia
Guo, Yue-Wei
author_sort He, Wen-Fei
collection PubMed
description Two new indole alkaloids, hainanerectamines A (1) and B (2), and one new β-carboline alkaloids, hainanerectamines C (4), along with five known related alkaloids (3, 5–8), have been isolated from the Hainan marine sponge Hyrtios erecta. The structures of new compounds 1, 2 and 4 were determined by detailed analysis of their 1D and 2D NMR spectra and by comparison of their spectroscopic data with those of related model compounds. Compounds 2–4 exhibited moderate inhibitory activity against Aurora A, a member of serine/threonine kinase family involving in the regulation of cell division and a new target in cancer treatment, with IC(50) values of 24.5, 13.6, and 18.6 μg/mL, respectively.
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spelling pubmed-41138102014-07-29 Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta He, Wen-Fei Xue, Duo-Qing Yao, Li-Gong Li, Jing-Ya Li, Jia Guo, Yue-Wei Mar Drugs Article Two new indole alkaloids, hainanerectamines A (1) and B (2), and one new β-carboline alkaloids, hainanerectamines C (4), along with five known related alkaloids (3, 5–8), have been isolated from the Hainan marine sponge Hyrtios erecta. The structures of new compounds 1, 2 and 4 were determined by detailed analysis of their 1D and 2D NMR spectra and by comparison of their spectroscopic data with those of related model compounds. Compounds 2–4 exhibited moderate inhibitory activity against Aurora A, a member of serine/threonine kinase family involving in the regulation of cell division and a new target in cancer treatment, with IC(50) values of 24.5, 13.6, and 18.6 μg/mL, respectively. MDPI 2014-06-30 /pmc/articles/PMC4113810/ /pubmed/24983641 http://dx.doi.org/10.3390/md12073982 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
He, Wen-Fei
Xue, Duo-Qing
Yao, Li-Gong
Li, Jing-Ya
Li, Jia
Guo, Yue-Wei
Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta
title Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta
title_full Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta
title_fullStr Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta
title_full_unstemmed Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta
title_short Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta
title_sort hainanerectamines a–c, alkaloids from the hainan sponge hyrtios erecta
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113810/
https://www.ncbi.nlm.nih.gov/pubmed/24983641
http://dx.doi.org/10.3390/md12073982
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