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Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice

Enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available. In this work, we found that the number of B cells was reduced in enterovirus 71-infected mice. Deferoxamine, a marine microb...

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Autores principales: Yang, Yajun, Ma, Jing, Xiu, Jinghui, Bai, Lin, Guan, Feifei, Zhang, Li, Liu, Jiangning, Zhang, Lianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113816/
https://www.ncbi.nlm.nih.gov/pubmed/25003792
http://dx.doi.org/10.3390/md12074086
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author Yang, Yajun
Ma, Jing
Xiu, Jinghui
Bai, Lin
Guan, Feifei
Zhang, Li
Liu, Jiangning
Zhang, Lianfeng
author_facet Yang, Yajun
Ma, Jing
Xiu, Jinghui
Bai, Lin
Guan, Feifei
Zhang, Li
Liu, Jiangning
Zhang, Lianfeng
author_sort Yang, Yajun
collection PubMed
description Enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available. In this work, we found that the number of B cells was reduced in enterovirus 71-infected mice. Deferoxamine, a marine microbial natural product, compensated for the decreased levels of B cells caused by enterovirus 71 infection. The neutralizing antibody titer was also improved after deferoxamine treatment. Furthermore, deferoxamine relieved symptoms and reduced mortality and muscle damage caused by enterovirus 71 infection. This work suggested that deferoxamine has the potential for further development as a B cell-immunomodulator against enterovirus 71.
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spelling pubmed-41138162014-07-29 Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice Yang, Yajun Ma, Jing Xiu, Jinghui Bai, Lin Guan, Feifei Zhang, Li Liu, Jiangning Zhang, Lianfeng Mar Drugs Article Enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available. In this work, we found that the number of B cells was reduced in enterovirus 71-infected mice. Deferoxamine, a marine microbial natural product, compensated for the decreased levels of B cells caused by enterovirus 71 infection. The neutralizing antibody titer was also improved after deferoxamine treatment. Furthermore, deferoxamine relieved symptoms and reduced mortality and muscle damage caused by enterovirus 71 infection. This work suggested that deferoxamine has the potential for further development as a B cell-immunomodulator against enterovirus 71. MDPI 2014-07-07 /pmc/articles/PMC4113816/ /pubmed/25003792 http://dx.doi.org/10.3390/md12074086 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yang, Yajun
Ma, Jing
Xiu, Jinghui
Bai, Lin
Guan, Feifei
Zhang, Li
Liu, Jiangning
Zhang, Lianfeng
Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice
title Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice
title_full Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice
title_fullStr Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice
title_full_unstemmed Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice
title_short Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice
title_sort deferoxamine compensates for decreases in b cell counts and reduces mortality in enterovirus 71-infected mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113816/
https://www.ncbi.nlm.nih.gov/pubmed/25003792
http://dx.doi.org/10.3390/md12074086
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