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Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice
Enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available. In this work, we found that the number of B cells was reduced in enterovirus 71-infected mice. Deferoxamine, a marine microb...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113816/ https://www.ncbi.nlm.nih.gov/pubmed/25003792 http://dx.doi.org/10.3390/md12074086 |
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author | Yang, Yajun Ma, Jing Xiu, Jinghui Bai, Lin Guan, Feifei Zhang, Li Liu, Jiangning Zhang, Lianfeng |
author_facet | Yang, Yajun Ma, Jing Xiu, Jinghui Bai, Lin Guan, Feifei Zhang, Li Liu, Jiangning Zhang, Lianfeng |
author_sort | Yang, Yajun |
collection | PubMed |
description | Enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available. In this work, we found that the number of B cells was reduced in enterovirus 71-infected mice. Deferoxamine, a marine microbial natural product, compensated for the decreased levels of B cells caused by enterovirus 71 infection. The neutralizing antibody titer was also improved after deferoxamine treatment. Furthermore, deferoxamine relieved symptoms and reduced mortality and muscle damage caused by enterovirus 71 infection. This work suggested that deferoxamine has the potential for further development as a B cell-immunomodulator against enterovirus 71. |
format | Online Article Text |
id | pubmed-4113816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-41138162014-07-29 Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice Yang, Yajun Ma, Jing Xiu, Jinghui Bai, Lin Guan, Feifei Zhang, Li Liu, Jiangning Zhang, Lianfeng Mar Drugs Article Enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available. In this work, we found that the number of B cells was reduced in enterovirus 71-infected mice. Deferoxamine, a marine microbial natural product, compensated for the decreased levels of B cells caused by enterovirus 71 infection. The neutralizing antibody titer was also improved after deferoxamine treatment. Furthermore, deferoxamine relieved symptoms and reduced mortality and muscle damage caused by enterovirus 71 infection. This work suggested that deferoxamine has the potential for further development as a B cell-immunomodulator against enterovirus 71. MDPI 2014-07-07 /pmc/articles/PMC4113816/ /pubmed/25003792 http://dx.doi.org/10.3390/md12074086 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Yang, Yajun Ma, Jing Xiu, Jinghui Bai, Lin Guan, Feifei Zhang, Li Liu, Jiangning Zhang, Lianfeng Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice |
title | Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice |
title_full | Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice |
title_fullStr | Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice |
title_full_unstemmed | Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice |
title_short | Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice |
title_sort | deferoxamine compensates for decreases in b cell counts and reduces mortality in enterovirus 71-infected mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113816/ https://www.ncbi.nlm.nih.gov/pubmed/25003792 http://dx.doi.org/10.3390/md12074086 |
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