Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer’s disease

In Alzheimer’s disease (AD), abnormal sphingolipid metabolism has been reported, although the pathogenic consequences of these changes have not been fully characterized. We show that acid sphingomyelinase (ASM) is increased in fibroblasts, brain, and/or plasma from patients with AD and in AD mice, l...

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Detalles Bibliográficos
Autores principales: Lee, Jong Kil, Jin, Hee Kyung, Park, Min Hee, Kim, Bo-ra, Lee, Phil Hyu, Nakauchi, Hiromitsu, Carter, Janet E., He, Xingxuan, Schuchman, Edward H., Bae, Jae-sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113944/
https://www.ncbi.nlm.nih.gov/pubmed/25049335
http://dx.doi.org/10.1084/jem.20132451

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