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Fibroblast heterogeneity in the cancer wound

Fibroblasts regulate the structure and function of healthy tissues, participate transiently in tissue repair after acute inflammation, and assume an aberrant stimulatory role during chronic inflammatory states including cancer. Such cancer-associated fibroblasts (CAFs) modulate the tumor microenviro...

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Detalles Bibliográficos
Autores principales: Öhlund, Daniel, Elyada, Ela, Tuveson, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113948/
https://www.ncbi.nlm.nih.gov/pubmed/25071162
http://dx.doi.org/10.1084/jem.20140692
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author Öhlund, Daniel
Elyada, Ela
Tuveson, David
author_facet Öhlund, Daniel
Elyada, Ela
Tuveson, David
author_sort Öhlund, Daniel
collection PubMed
description Fibroblasts regulate the structure and function of healthy tissues, participate transiently in tissue repair after acute inflammation, and assume an aberrant stimulatory role during chronic inflammatory states including cancer. Such cancer-associated fibroblasts (CAFs) modulate the tumor microenvironment and influence the behavior of neoplastic cells in either a tumor-promoting or tumor-inhibiting manner. These pleiotropic functions highlight the inherent plasticity of fibroblasts and may provide new avenues to understand and therapeutically intervene in malignancies. We discuss the emerging themes of CAF biology in the context of tumorigenesis and therapy.
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spelling pubmed-41139482015-01-28 Fibroblast heterogeneity in the cancer wound Öhlund, Daniel Elyada, Ela Tuveson, David J Exp Med Review Fibroblasts regulate the structure and function of healthy tissues, participate transiently in tissue repair after acute inflammation, and assume an aberrant stimulatory role during chronic inflammatory states including cancer. Such cancer-associated fibroblasts (CAFs) modulate the tumor microenvironment and influence the behavior of neoplastic cells in either a tumor-promoting or tumor-inhibiting manner. These pleiotropic functions highlight the inherent plasticity of fibroblasts and may provide new avenues to understand and therapeutically intervene in malignancies. We discuss the emerging themes of CAF biology in the context of tumorigenesis and therapy. The Rockefeller University Press 2014-07-28 /pmc/articles/PMC4113948/ /pubmed/25071162 http://dx.doi.org/10.1084/jem.20140692 Text en © 2014 Öhlund et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Review
Öhlund, Daniel
Elyada, Ela
Tuveson, David
Fibroblast heterogeneity in the cancer wound
title Fibroblast heterogeneity in the cancer wound
title_full Fibroblast heterogeneity in the cancer wound
title_fullStr Fibroblast heterogeneity in the cancer wound
title_full_unstemmed Fibroblast heterogeneity in the cancer wound
title_short Fibroblast heterogeneity in the cancer wound
title_sort fibroblast heterogeneity in the cancer wound
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113948/
https://www.ncbi.nlm.nih.gov/pubmed/25071162
http://dx.doi.org/10.1084/jem.20140692
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