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Fibroblast heterogeneity in the cancer wound
Fibroblasts regulate the structure and function of healthy tissues, participate transiently in tissue repair after acute inflammation, and assume an aberrant stimulatory role during chronic inflammatory states including cancer. Such cancer-associated fibroblasts (CAFs) modulate the tumor microenviro...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113948/ https://www.ncbi.nlm.nih.gov/pubmed/25071162 http://dx.doi.org/10.1084/jem.20140692 |
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author | Öhlund, Daniel Elyada, Ela Tuveson, David |
author_facet | Öhlund, Daniel Elyada, Ela Tuveson, David |
author_sort | Öhlund, Daniel |
collection | PubMed |
description | Fibroblasts regulate the structure and function of healthy tissues, participate transiently in tissue repair after acute inflammation, and assume an aberrant stimulatory role during chronic inflammatory states including cancer. Such cancer-associated fibroblasts (CAFs) modulate the tumor microenvironment and influence the behavior of neoplastic cells in either a tumor-promoting or tumor-inhibiting manner. These pleiotropic functions highlight the inherent plasticity of fibroblasts and may provide new avenues to understand and therapeutically intervene in malignancies. We discuss the emerging themes of CAF biology in the context of tumorigenesis and therapy. |
format | Online Article Text |
id | pubmed-4113948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-41139482015-01-28 Fibroblast heterogeneity in the cancer wound Öhlund, Daniel Elyada, Ela Tuveson, David J Exp Med Review Fibroblasts regulate the structure and function of healthy tissues, participate transiently in tissue repair after acute inflammation, and assume an aberrant stimulatory role during chronic inflammatory states including cancer. Such cancer-associated fibroblasts (CAFs) modulate the tumor microenvironment and influence the behavior of neoplastic cells in either a tumor-promoting or tumor-inhibiting manner. These pleiotropic functions highlight the inherent plasticity of fibroblasts and may provide new avenues to understand and therapeutically intervene in malignancies. We discuss the emerging themes of CAF biology in the context of tumorigenesis and therapy. The Rockefeller University Press 2014-07-28 /pmc/articles/PMC4113948/ /pubmed/25071162 http://dx.doi.org/10.1084/jem.20140692 Text en © 2014 Öhlund et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Review Öhlund, Daniel Elyada, Ela Tuveson, David Fibroblast heterogeneity in the cancer wound |
title | Fibroblast heterogeneity in the cancer wound |
title_full | Fibroblast heterogeneity in the cancer wound |
title_fullStr | Fibroblast heterogeneity in the cancer wound |
title_full_unstemmed | Fibroblast heterogeneity in the cancer wound |
title_short | Fibroblast heterogeneity in the cancer wound |
title_sort | fibroblast heterogeneity in the cancer wound |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113948/ https://www.ncbi.nlm.nih.gov/pubmed/25071162 http://dx.doi.org/10.1084/jem.20140692 |
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