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Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures

The loss of synapses is a strong histological correlate of the cognitive decline in Alzheimer's disease (AD). Amyloid β−peptide (Aβ), a cleavage product of the amyloid precursor protein (APP), exerts detrimental effects on synapses, a process thought to be causally related to the cognitive defi...

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Detalles Bibliográficos
Autores principales:	Liebscher, S, Page, R M, Käfer, K, Winkler, E, Quinn, K, Goldbach, E, Brigham, E F, Quincy, D, Basi, G S, Schenk, D B, Steiner, H, Bonhoeffer, T, Haass, C, Meyer-Luehmann, M, Hübener, M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113951/ https://www.ncbi.nlm.nih.gov/pubmed/24061497 http://dx.doi.org/10.1038/mp.2013.122

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