Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks

Metabolic pathways in eubacteria and archaea often are encoded by operons and/or gene clusters (genome neighborhoods) that provide important clues for assignment of both enzyme functions and metabolic pathways. We describe a bioinformatic approach (genome neighborhood network; GNN) that enables larg...

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Detalles Bibliográficos
Autores principales: Zhao, Suwen, Sakai, Ayano, Zhang, Xinshuai, Vetting, Matthew W, Kumar, Ritesh, Hillerich, Brandan, San Francisco, Brian, Solbiati, Jose, Steves, Adam, Brown, Shoshana, Akiva, Eyal, Barber, Alan, Seidel, Ronald D, Babbitt, Patricia C, Almo, Steven C, Gerlt, John A, Jacobson, Matthew P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113996/
https://www.ncbi.nlm.nih.gov/pubmed/24980702
http://dx.doi.org/10.7554/eLife.03275

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