Cargando…
Cardiovascular Risks in Prediabetes: Preliminary Data on “Vasculopathy Triad”
BACKGROUND: Subclinical cardiovascular disease is inherent in complications of diabetes mellitus. It occurs before the obvert manifestation of cardiovascular disease complication in diabetes, and involves vasculopathy triad or three major vascular events comprising stasis, endothelial dysfunction, a...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114010/ https://www.ncbi.nlm.nih.gov/pubmed/25077081 http://dx.doi.org/10.4103/1947-2714.136913 |
_version_ | 1782328381153476608 |
---|---|
author | Nwose, Ezekiel U Richards, Ross S Bwititi, Phillip T |
author_facet | Nwose, Ezekiel U Richards, Ross S Bwititi, Phillip T |
author_sort | Nwose, Ezekiel U |
collection | PubMed |
description | BACKGROUND: Subclinical cardiovascular disease is inherent in complications of diabetes mellitus. It occurs before the obvert manifestation of cardiovascular disease complication in diabetes, and involves vasculopathy triad or three major vascular events comprising stasis, endothelial dysfunction, and atherothrombosis. AIM: This study was to examine evidence of vasculopathy triad in prediabetes, biomarkers of stasis, endothelial dysfunction, and atherothrombosis in prediabetes were compared with apparently healthy group. MATERIALS AND METHODS: Eighty-one participants with results for plasma D-dimer, homocysteine, and whole blood viscosity were selected from a research database. The participants consisted of control (n = 44) and prediabetes (n = 37) based on clinical history and laboratory results. RESULTS: Multivariate analysis shows a significantly higher level of vasculopathy in prediabetes than in the control group (P > 0.0001). Blood viscosity (P < 0.04) and homocysteine (P < 0.03) are significantly higher in prediabetes than in controls. Average levels for plasma D-dimer are also higher in prediabetes than in control, but not statistically significant in this particular analysis. CONCLUSION: This study suggests a novel application of known idea, vasculopathy triad that could be used for assessment of subclinical cardiovascular disease in prediabetes. |
format | Online Article Text |
id | pubmed-4114010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41140102014-07-30 Cardiovascular Risks in Prediabetes: Preliminary Data on “Vasculopathy Triad” Nwose, Ezekiel U Richards, Ross S Bwititi, Phillip T N Am J Med Sci Original Article BACKGROUND: Subclinical cardiovascular disease is inherent in complications of diabetes mellitus. It occurs before the obvert manifestation of cardiovascular disease complication in diabetes, and involves vasculopathy triad or three major vascular events comprising stasis, endothelial dysfunction, and atherothrombosis. AIM: This study was to examine evidence of vasculopathy triad in prediabetes, biomarkers of stasis, endothelial dysfunction, and atherothrombosis in prediabetes were compared with apparently healthy group. MATERIALS AND METHODS: Eighty-one participants with results for plasma D-dimer, homocysteine, and whole blood viscosity were selected from a research database. The participants consisted of control (n = 44) and prediabetes (n = 37) based on clinical history and laboratory results. RESULTS: Multivariate analysis shows a significantly higher level of vasculopathy in prediabetes than in the control group (P > 0.0001). Blood viscosity (P < 0.04) and homocysteine (P < 0.03) are significantly higher in prediabetes than in controls. Average levels for plasma D-dimer are also higher in prediabetes than in control, but not statistically significant in this particular analysis. CONCLUSION: This study suggests a novel application of known idea, vasculopathy triad that could be used for assessment of subclinical cardiovascular disease in prediabetes. Medknow Publications & Media Pvt Ltd 2014-07 /pmc/articles/PMC4114010/ /pubmed/25077081 http://dx.doi.org/10.4103/1947-2714.136913 Text en Copyright: © North American Journal of Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Nwose, Ezekiel U Richards, Ross S Bwititi, Phillip T Cardiovascular Risks in Prediabetes: Preliminary Data on “Vasculopathy Triad” |
title | Cardiovascular Risks in Prediabetes: Preliminary Data on “Vasculopathy Triad” |
title_full | Cardiovascular Risks in Prediabetes: Preliminary Data on “Vasculopathy Triad” |
title_fullStr | Cardiovascular Risks in Prediabetes: Preliminary Data on “Vasculopathy Triad” |
title_full_unstemmed | Cardiovascular Risks in Prediabetes: Preliminary Data on “Vasculopathy Triad” |
title_short | Cardiovascular Risks in Prediabetes: Preliminary Data on “Vasculopathy Triad” |
title_sort | cardiovascular risks in prediabetes: preliminary data on “vasculopathy triad” |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114010/ https://www.ncbi.nlm.nih.gov/pubmed/25077081 http://dx.doi.org/10.4103/1947-2714.136913 |
work_keys_str_mv | AT nwoseezekielu cardiovascularrisksinprediabetespreliminarydataonvasculopathytriad AT richardsrosss cardiovascularrisksinprediabetespreliminarydataonvasculopathytriad AT bwititiphillipt cardiovascularrisksinprediabetespreliminarydataonvasculopathytriad |