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Vitamin D deficiency in Korean children: prevalence, risk factors, and the relationship with parathyroid hormone levels

PURPOSE: This study was performed to investigate the relationship between serum vitamin D and parathyroid hormone (PTH) levels as well as to describe the prevalence and the risk factors of vitamin D deficiency (VDD) in Korean children. METHODS: Participants were 1,212 children aged 4 to 15 years, wh...

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Autores principales: Chung, In Hyuk, Kim, Hae Jung, Chung, Sochung, Yoo, Eun-Gyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pediatric Endocrinology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114049/
https://www.ncbi.nlm.nih.gov/pubmed/25077091
http://dx.doi.org/10.6065/apem.2014.19.2.86
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author Chung, In Hyuk
Kim, Hae Jung
Chung, Sochung
Yoo, Eun-Gyong
author_facet Chung, In Hyuk
Kim, Hae Jung
Chung, Sochung
Yoo, Eun-Gyong
author_sort Chung, In Hyuk
collection PubMed
description PURPOSE: This study was performed to investigate the relationship between serum vitamin D and parathyroid hormone (PTH) levels as well as to describe the prevalence and the risk factors of vitamin D deficiency (VDD) in Korean children. METHODS: Participants were 1,212 children aged 4 to 15 years, who visited Bundang CHA Medical Center (located at 37°N) between March 2012 and February 2013. Overweight was defined as body mass index≥85th percentile. Participants were divided into 4 age groups and 2 seasonal groups. VDD was defined by serum 25-hydroxyvitamin D (25OHD) <20 ng/mL. RESULTS: The level of 25OHD was significantly lower in overweight group than in normal weight group (17.1±5.1 ng/mL vs. 19.1±6.1 ng/mL, P<0.001). Winter-spring season (odds ratio [OR], 4.46; 95% confidence interval [CI], 3.45-5.77), older age group (OR, 1.60; 95% CI, 1.36-1.88), and overweight (OR, 2.21; 95% CI, 1.62-3.01) were independently related with VDD. The PTH levels were significantly higher in VDD group compared to vitamin D insufficiency and sufficiency group (P<0.001). In normal weight children, 25OHD (β=-0.007, P<0.001) and ionized calcium (β=-0.594, P=0.007) were independently related with PTH, however, these associations were not significant in overweight children. CONCLUSION: VDD is very common in Korean children and its prevalence increases in winter-spring season, in overweight children and in older age groups. Further investigation on the vitamin D and PTH metabolism according to adiposity is required.
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spelling pubmed-41140492014-07-30 Vitamin D deficiency in Korean children: prevalence, risk factors, and the relationship with parathyroid hormone levels Chung, In Hyuk Kim, Hae Jung Chung, Sochung Yoo, Eun-Gyong Ann Pediatr Endocrinol Metab Original Article PURPOSE: This study was performed to investigate the relationship between serum vitamin D and parathyroid hormone (PTH) levels as well as to describe the prevalence and the risk factors of vitamin D deficiency (VDD) in Korean children. METHODS: Participants were 1,212 children aged 4 to 15 years, who visited Bundang CHA Medical Center (located at 37°N) between March 2012 and February 2013. Overweight was defined as body mass index≥85th percentile. Participants were divided into 4 age groups and 2 seasonal groups. VDD was defined by serum 25-hydroxyvitamin D (25OHD) <20 ng/mL. RESULTS: The level of 25OHD was significantly lower in overweight group than in normal weight group (17.1±5.1 ng/mL vs. 19.1±6.1 ng/mL, P<0.001). Winter-spring season (odds ratio [OR], 4.46; 95% confidence interval [CI], 3.45-5.77), older age group (OR, 1.60; 95% CI, 1.36-1.88), and overweight (OR, 2.21; 95% CI, 1.62-3.01) were independently related with VDD. The PTH levels were significantly higher in VDD group compared to vitamin D insufficiency and sufficiency group (P<0.001). In normal weight children, 25OHD (β=-0.007, P<0.001) and ionized calcium (β=-0.594, P=0.007) were independently related with PTH, however, these associations were not significant in overweight children. CONCLUSION: VDD is very common in Korean children and its prevalence increases in winter-spring season, in overweight children and in older age groups. Further investigation on the vitamin D and PTH metabolism according to adiposity is required. The Korean Society of Pediatric Endocrinology 2014-06 2014-06-30 /pmc/articles/PMC4114049/ /pubmed/25077091 http://dx.doi.org/10.6065/apem.2014.19.2.86 Text en © 2014 Annals of Pediatric Endocrinology & Metabolism http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chung, In Hyuk
Kim, Hae Jung
Chung, Sochung
Yoo, Eun-Gyong
Vitamin D deficiency in Korean children: prevalence, risk factors, and the relationship with parathyroid hormone levels
title Vitamin D deficiency in Korean children: prevalence, risk factors, and the relationship with parathyroid hormone levels
title_full Vitamin D deficiency in Korean children: prevalence, risk factors, and the relationship with parathyroid hormone levels
title_fullStr Vitamin D deficiency in Korean children: prevalence, risk factors, and the relationship with parathyroid hormone levels
title_full_unstemmed Vitamin D deficiency in Korean children: prevalence, risk factors, and the relationship with parathyroid hormone levels
title_short Vitamin D deficiency in Korean children: prevalence, risk factors, and the relationship with parathyroid hormone levels
title_sort vitamin d deficiency in korean children: prevalence, risk factors, and the relationship with parathyroid hormone levels
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114049/
https://www.ncbi.nlm.nih.gov/pubmed/25077091
http://dx.doi.org/10.6065/apem.2014.19.2.86
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