Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture

BACKGROUND: Organotypic tumor spheroids, a 3D in vitro model derived from patient tumor material, preserve tissue heterogeneity and retain structural tissue elements, thus replicating the in vivo tumor more closely than commonly used 2D and 3D cell line models. Such structures harbour tumorigenic ce...

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Detalles Bibliográficos
Autores principales: Rajcevic, Uros, Knol, Jaco C, Piersma, Sander, Bougnaud, Sébastien, Fack, Fred, Sundlisaeter, Eirik, Søndenaa, Karl, Myklebust, Reidar, Pham, Thang V, Niclou, Simone P, Jiménez, Connie R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114130/
https://www.ncbi.nlm.nih.gov/pubmed/25075203
http://dx.doi.org/10.1186/1477-5956-12-39

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