Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson’s disease

BACKGROUND: The substantia nigra (SN) midbrain nucleus is constitutively iron rich. Iron levels elevate further with age, and pathologically in Parkinson’s disease (PD). Iron accumulation in PD SN involves dysfunction of ceruloplasmin (CP), which normally promotes iron export. We previously showed t...

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Detalles Bibliográficos
Autores principales: Ayton, Scott, Lei, Peng, Adlard, Paul A, Volitakis, Irene, Cherny, Robert A, Bush, Ashley I, Finkelstein, David I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114139/
https://www.ncbi.nlm.nih.gov/pubmed/25011704
http://dx.doi.org/10.1186/1750-1326-9-27

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