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Relationships between Personality Traits, Medial Temporal Lobe Atrophy, and White Matter Lesion in Subjects Suffering from Mild Cognitive Impairment

Mild cognitive impairment (MCI) is a heterogeneous cognitive status that can be a prodromal stage of Alzheimer’s disease (AD). It is particularly relevant to focus on prodromal stages of AD such as MCI, because patho-physiological abnormalities of AD start years before the dementia stage. Medial tem...

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Autores principales: Duron, Emmanuelle, Vidal, Jean-Sébastien, Bounatiro, Samira, Ben Ahmed, Sana, Seux, Marie-Laure, Rigaud, Anne-Sophie, Hanon, Olivier, Viollet, Cécile, Epelbaum, Jacques, Martel, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114211/
https://www.ncbi.nlm.nih.gov/pubmed/25120483
http://dx.doi.org/10.3389/fnagi.2014.00195
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author Duron, Emmanuelle
Vidal, Jean-Sébastien
Bounatiro, Samira
Ben Ahmed, Sana
Seux, Marie-Laure
Rigaud, Anne-Sophie
Hanon, Olivier
Viollet, Cécile
Epelbaum, Jacques
Martel, Guillaume
author_facet Duron, Emmanuelle
Vidal, Jean-Sébastien
Bounatiro, Samira
Ben Ahmed, Sana
Seux, Marie-Laure
Rigaud, Anne-Sophie
Hanon, Olivier
Viollet, Cécile
Epelbaum, Jacques
Martel, Guillaume
author_sort Duron, Emmanuelle
collection PubMed
description Mild cognitive impairment (MCI) is a heterogeneous cognitive status that can be a prodromal stage of Alzheimer’s disease (AD). It is particularly relevant to focus on prodromal stages of AD such as MCI, because patho-physiological abnormalities of AD start years before the dementia stage. Medial temporal lobe (MTL) atrophy resulting from AD lesions and cerebrovascular lesions [i.e., white matter lesions (WML), lacunar strokes, and strokes] are often revealed concurrently on magnetic resonance imaging (MRI) in MCI subjects. Personality changes have been reported to be associated with MCI status and early AD. More specifically, an increase in neuroticism and a decrease in conscientiousness have been reported, suggesting that higher and lower scores, respectively, in neuroticism and conscientiousness are associated with an increased risk of developing the disease. However, personality changes have not been studied concomitantly with pathological structural brain alterations detected on MRI in patients suffering from MCI. Therefore, the objective of the present study was to assess the relationship between MTL atrophy, WML, lacunar strokes, and personality traits in such patients. The severity of WML was strongly associated with lower levels of conscientiousness and higher levels of neuroticism. Conversely, no association was detected between personality traits and the presence of lacunar strokes or MTL atrophy. Altogether, these results strongly suggest that personality changes occurring in a MCI population, at high risk of AD, are associated with WML, which can induce executive dysfunctions, rather than with MTL atrophy.
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spelling pubmed-41142112014-08-12 Relationships between Personality Traits, Medial Temporal Lobe Atrophy, and White Matter Lesion in Subjects Suffering from Mild Cognitive Impairment Duron, Emmanuelle Vidal, Jean-Sébastien Bounatiro, Samira Ben Ahmed, Sana Seux, Marie-Laure Rigaud, Anne-Sophie Hanon, Olivier Viollet, Cécile Epelbaum, Jacques Martel, Guillaume Front Aging Neurosci Neuroscience Mild cognitive impairment (MCI) is a heterogeneous cognitive status that can be a prodromal stage of Alzheimer’s disease (AD). It is particularly relevant to focus on prodromal stages of AD such as MCI, because patho-physiological abnormalities of AD start years before the dementia stage. Medial temporal lobe (MTL) atrophy resulting from AD lesions and cerebrovascular lesions [i.e., white matter lesions (WML), lacunar strokes, and strokes] are often revealed concurrently on magnetic resonance imaging (MRI) in MCI subjects. Personality changes have been reported to be associated with MCI status and early AD. More specifically, an increase in neuroticism and a decrease in conscientiousness have been reported, suggesting that higher and lower scores, respectively, in neuroticism and conscientiousness are associated with an increased risk of developing the disease. However, personality changes have not been studied concomitantly with pathological structural brain alterations detected on MRI in patients suffering from MCI. Therefore, the objective of the present study was to assess the relationship between MTL atrophy, WML, lacunar strokes, and personality traits in such patients. The severity of WML was strongly associated with lower levels of conscientiousness and higher levels of neuroticism. Conversely, no association was detected between personality traits and the presence of lacunar strokes or MTL atrophy. Altogether, these results strongly suggest that personality changes occurring in a MCI population, at high risk of AD, are associated with WML, which can induce executive dysfunctions, rather than with MTL atrophy. Frontiers Media S.A. 2014-07-29 /pmc/articles/PMC4114211/ /pubmed/25120483 http://dx.doi.org/10.3389/fnagi.2014.00195 Text en Copyright © 2014 Duron, Vidal, Bounatiro, Ben Ahmed, Seux, Rigaud, Hanon, Viollet, Epelbaum and Martel. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Duron, Emmanuelle
Vidal, Jean-Sébastien
Bounatiro, Samira
Ben Ahmed, Sana
Seux, Marie-Laure
Rigaud, Anne-Sophie
Hanon, Olivier
Viollet, Cécile
Epelbaum, Jacques
Martel, Guillaume
Relationships between Personality Traits, Medial Temporal Lobe Atrophy, and White Matter Lesion in Subjects Suffering from Mild Cognitive Impairment
title Relationships between Personality Traits, Medial Temporal Lobe Atrophy, and White Matter Lesion in Subjects Suffering from Mild Cognitive Impairment
title_full Relationships between Personality Traits, Medial Temporal Lobe Atrophy, and White Matter Lesion in Subjects Suffering from Mild Cognitive Impairment
title_fullStr Relationships between Personality Traits, Medial Temporal Lobe Atrophy, and White Matter Lesion in Subjects Suffering from Mild Cognitive Impairment
title_full_unstemmed Relationships between Personality Traits, Medial Temporal Lobe Atrophy, and White Matter Lesion in Subjects Suffering from Mild Cognitive Impairment
title_short Relationships between Personality Traits, Medial Temporal Lobe Atrophy, and White Matter Lesion in Subjects Suffering from Mild Cognitive Impairment
title_sort relationships between personality traits, medial temporal lobe atrophy, and white matter lesion in subjects suffering from mild cognitive impairment
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114211/
https://www.ncbi.nlm.nih.gov/pubmed/25120483
http://dx.doi.org/10.3389/fnagi.2014.00195
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