Cargando…

Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Medical and surgical management for pulmonary arterial hypertension

Prior to the availability of the pulmonary arterial hypertension (PAH)-specific therapy, PAH was a dreadful disease with a very poor prognosis. Better understanding of the complex pathobiology of PAH has led to a major therapeutic evolution. International regulatory agencies have approved many speci...

Descripción completa

Detalles Bibliográficos
Autores principales: Idrees, Majdy M., Swiston, John, Nizami, Imran, Al Dalaan, Abdullah, Levy, Robert D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114282/
https://www.ncbi.nlm.nih.gov/pubmed/25077002
http://dx.doi.org/10.4103/1817-1737.134043
_version_ 1782328413854367744
author Idrees, Majdy M.
Swiston, John
Nizami, Imran
Al Dalaan, Abdullah
Levy, Robert D.
author_facet Idrees, Majdy M.
Swiston, John
Nizami, Imran
Al Dalaan, Abdullah
Levy, Robert D.
author_sort Idrees, Majdy M.
collection PubMed
description Prior to the availability of the pulmonary arterial hypertension (PAH)-specific therapy, PAH was a dreadful disease with a very poor prognosis. Better understanding of the complex pathobiology of PAH has led to a major therapeutic evolution. International regulatory agencies have approved many specific drugs with different pharmacologic pathways and routes of administration. In the year 2013, two new drugs with great potentials in managing PAH have been added to the treatment options, macitentan and riociguat. Additional drugs are expected to come in the near future. A substantial body of evidence has confirmed the effectiveness of pulmonary arterial hypertension (PAH)-specific therapies in improving the patients’ symptomatic status and slowing down the rate of clinical deterioration. Although the newer modern medications have significantly improved the survival of patients with PAH, it remains a non-curable and fatal disease. Lung transplantation (LT) remains the only therapeutic option for selected patients with advanced disease who continue to deteriorate despite optimal therapy.
format Online
Article
Text
id pubmed-4114282
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-41142822014-07-30 Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Medical and surgical management for pulmonary arterial hypertension Idrees, Majdy M. Swiston, John Nizami, Imran Al Dalaan, Abdullah Levy, Robert D. Ann Thorac Med Guidelines Prior to the availability of the pulmonary arterial hypertension (PAH)-specific therapy, PAH was a dreadful disease with a very poor prognosis. Better understanding of the complex pathobiology of PAH has led to a major therapeutic evolution. International regulatory agencies have approved many specific drugs with different pharmacologic pathways and routes of administration. In the year 2013, two new drugs with great potentials in managing PAH have been added to the treatment options, macitentan and riociguat. Additional drugs are expected to come in the near future. A substantial body of evidence has confirmed the effectiveness of pulmonary arterial hypertension (PAH)-specific therapies in improving the patients’ symptomatic status and slowing down the rate of clinical deterioration. Although the newer modern medications have significantly improved the survival of patients with PAH, it remains a non-curable and fatal disease. Lung transplantation (LT) remains the only therapeutic option for selected patients with advanced disease who continue to deteriorate despite optimal therapy. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4114282/ /pubmed/25077002 http://dx.doi.org/10.4103/1817-1737.134043 Text en Copyright: © Annals of Thoracic Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Guidelines
Idrees, Majdy M.
Swiston, John
Nizami, Imran
Al Dalaan, Abdullah
Levy, Robert D.
Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Medical and surgical management for pulmonary arterial hypertension
title Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Medical and surgical management for pulmonary arterial hypertension
title_full Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Medical and surgical management for pulmonary arterial hypertension
title_fullStr Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Medical and surgical management for pulmonary arterial hypertension
title_full_unstemmed Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Medical and surgical management for pulmonary arterial hypertension
title_short Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Medical and surgical management for pulmonary arterial hypertension
title_sort saudi guidelines on the diagnosis and treatment of pulmonary hypertension: medical and surgical management for pulmonary arterial hypertension
topic Guidelines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114282/
https://www.ncbi.nlm.nih.gov/pubmed/25077002
http://dx.doi.org/10.4103/1817-1737.134043
work_keys_str_mv AT idreesmajdym saudiguidelinesonthediagnosisandtreatmentofpulmonaryhypertensionmedicalandsurgicalmanagementforpulmonaryarterialhypertension
AT swistonjohn saudiguidelinesonthediagnosisandtreatmentofpulmonaryhypertensionmedicalandsurgicalmanagementforpulmonaryarterialhypertension
AT nizamiimran saudiguidelinesonthediagnosisandtreatmentofpulmonaryhypertensionmedicalandsurgicalmanagementforpulmonaryarterialhypertension
AT aldalaanabdullah saudiguidelinesonthediagnosisandtreatmentofpulmonaryhypertensionmedicalandsurgicalmanagementforpulmonaryarterialhypertension
AT levyrobertd saudiguidelinesonthediagnosisandtreatmentofpulmonaryhypertensionmedicalandsurgicalmanagementforpulmonaryarterialhypertension