HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties

HTLV-1 and HTLV-2 share broad similarities in their overall genetic organization and expression pattern, but they differ substantially in their pathogenic properties. This review outlines distinctive features of HTLV-1 and HTLV-2 that might provide clues to explain their distinct clinical outcomes....

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Detalles Bibliográficos
Autores principales: Ciminale, Vincenzo, Rende, Francesca, Bertazzoni, Umberto, Romanelli, Maria G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114287/
https://www.ncbi.nlm.nih.gov/pubmed/25120538
http://dx.doi.org/10.3389/fmicb.2014.00398
Descripción
Sumario:HTLV-1 and HTLV-2 share broad similarities in their overall genetic organization and expression pattern, but they differ substantially in their pathogenic properties. This review outlines distinctive features of HTLV-1 and HTLV-2 that might provide clues to explain their distinct clinical outcomes. Differences in the kinetics of viral mRNA expression, functional properties of the regulatory and accessory proteins, and interactions with cellular factors and signal transduction pathways are discussed.

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