HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties

HTLV-1 and HTLV-2 share broad similarities in their overall genetic organization and expression pattern, but they differ substantially in their pathogenic properties. This review outlines distinctive features of HTLV-1 and HTLV-2 that might provide clues to explain their distinct clinical outcomes....

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Autores principales: Ciminale, Vincenzo, Rende, Francesca, Bertazzoni, Umberto, Romanelli, Maria G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114287/
https://www.ncbi.nlm.nih.gov/pubmed/25120538
http://dx.doi.org/10.3389/fmicb.2014.00398
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author Ciminale, Vincenzo
Rende, Francesca
Bertazzoni, Umberto
Romanelli, Maria G.
author_facet Ciminale, Vincenzo
Rende, Francesca
Bertazzoni, Umberto
Romanelli, Maria G.
author_sort Ciminale, Vincenzo
collection PubMed
description HTLV-1 and HTLV-2 share broad similarities in their overall genetic organization and expression pattern, but they differ substantially in their pathogenic properties. This review outlines distinctive features of HTLV-1 and HTLV-2 that might provide clues to explain their distinct clinical outcomes. Differences in the kinetics of viral mRNA expression, functional properties of the regulatory and accessory proteins, and interactions with cellular factors and signal transduction pathways are discussed.
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spelling pubmed-41142872014-08-12 HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties Ciminale, Vincenzo Rende, Francesca Bertazzoni, Umberto Romanelli, Maria G. Front Microbiol Neuroscience HTLV-1 and HTLV-2 share broad similarities in their overall genetic organization and expression pattern, but they differ substantially in their pathogenic properties. This review outlines distinctive features of HTLV-1 and HTLV-2 that might provide clues to explain their distinct clinical outcomes. Differences in the kinetics of viral mRNA expression, functional properties of the regulatory and accessory proteins, and interactions with cellular factors and signal transduction pathways are discussed. Frontiers Media S.A. 2014-07-29 /pmc/articles/PMC4114287/ /pubmed/25120538 http://dx.doi.org/10.3389/fmicb.2014.00398 Text en Copyright © 2014 Ciminale, Rende, Bertazzoni and Romanelli. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ciminale, Vincenzo
Rende, Francesca
Bertazzoni, Umberto
Romanelli, Maria G.
HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties
title HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties
title_full HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties
title_fullStr HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties
title_full_unstemmed HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties
title_short HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties
title_sort htlv-1 and htlv-2: highly similar viruses with distinct oncogenic properties
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114287/
https://www.ncbi.nlm.nih.gov/pubmed/25120538
http://dx.doi.org/10.3389/fmicb.2014.00398
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