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Evidence of promiscuous endothelial binding by Plasmodium falciparum‐infected erythrocytes
The adhesion of infected red blood cells (iRBCs) to human endothelium is considered a key event in the pathogenesis of cerebral malaria and other life‐threatening complications caused by the most prevalent malaria parasite Plasmodium falciparum. In the past 30 years, 14 endothelial receptors for iRB...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley-Blackwell
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114535/ https://www.ncbi.nlm.nih.gov/pubmed/24444337 http://dx.doi.org/10.1111/cmi.12270 |
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author | Esser, Claudia Bachmann, Anna Kuhn, Daniela Schuldt, Kathrin Förster, Birgit Thiel, Meike May, Jürgen Koch‐Nolte, Friedrich Yáñez‐Mó, María Sánchez‐Madrid, Francisco Schinkel, Alfred H. Jalkanen, Sirpa Craig, Alister G. Bruchhaus, Iris Horstmann, Rolf D. |
author_facet | Esser, Claudia Bachmann, Anna Kuhn, Daniela Schuldt, Kathrin Förster, Birgit Thiel, Meike May, Jürgen Koch‐Nolte, Friedrich Yáñez‐Mó, María Sánchez‐Madrid, Francisco Schinkel, Alfred H. Jalkanen, Sirpa Craig, Alister G. Bruchhaus, Iris Horstmann, Rolf D. |
author_sort | Esser, Claudia |
collection | PubMed |
description | The adhesion of infected red blood cells (iRBCs) to human endothelium is considered a key event in the pathogenesis of cerebral malaria and other life‐threatening complications caused by the most prevalent malaria parasite Plasmodium falciparum. In the past 30 years, 14 endothelial receptors for iRBCs have been identified. Exposing 10 additional surface proteins of endothelial cells to a mixture of P. falciparum isolates from three Ghanaian malaria patients, we identified seven new iRBC receptors, all expressed in brain vessels. This finding strongly suggests that endothelial binding of P. falciparum iRBCs is promiscuous and may use a combination of endothelial surface moieties. |
format | Online Article Text |
id | pubmed-4114535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Wiley-Blackwell |
record_format | MEDLINE/PubMed |
spelling | pubmed-41145352014-09-08 Evidence of promiscuous endothelial binding by Plasmodium falciparum‐infected erythrocytes Esser, Claudia Bachmann, Anna Kuhn, Daniela Schuldt, Kathrin Förster, Birgit Thiel, Meike May, Jürgen Koch‐Nolte, Friedrich Yáñez‐Mó, María Sánchez‐Madrid, Francisco Schinkel, Alfred H. Jalkanen, Sirpa Craig, Alister G. Bruchhaus, Iris Horstmann, Rolf D. Cell Microbiol Special Issue on Malaria The adhesion of infected red blood cells (iRBCs) to human endothelium is considered a key event in the pathogenesis of cerebral malaria and other life‐threatening complications caused by the most prevalent malaria parasite Plasmodium falciparum. In the past 30 years, 14 endothelial receptors for iRBCs have been identified. Exposing 10 additional surface proteins of endothelial cells to a mixture of P. falciparum isolates from three Ghanaian malaria patients, we identified seven new iRBC receptors, all expressed in brain vessels. This finding strongly suggests that endothelial binding of P. falciparum iRBCs is promiscuous and may use a combination of endothelial surface moieties. Wiley-Blackwell 2014-02-24 2014-05 /pmc/articles/PMC4114535/ /pubmed/24444337 http://dx.doi.org/10.1111/cmi.12270 Text en © 2014 The Authors. Cellular Microbiology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Special Issue on Malaria Esser, Claudia Bachmann, Anna Kuhn, Daniela Schuldt, Kathrin Förster, Birgit Thiel, Meike May, Jürgen Koch‐Nolte, Friedrich Yáñez‐Mó, María Sánchez‐Madrid, Francisco Schinkel, Alfred H. Jalkanen, Sirpa Craig, Alister G. Bruchhaus, Iris Horstmann, Rolf D. Evidence of promiscuous endothelial binding by Plasmodium falciparum‐infected erythrocytes |
title | Evidence of promiscuous endothelial binding by Plasmodium falciparum‐infected erythrocytes |
title_full | Evidence of promiscuous endothelial binding by Plasmodium falciparum‐infected erythrocytes |
title_fullStr | Evidence of promiscuous endothelial binding by Plasmodium falciparum‐infected erythrocytes |
title_full_unstemmed | Evidence of promiscuous endothelial binding by Plasmodium falciparum‐infected erythrocytes |
title_short | Evidence of promiscuous endothelial binding by Plasmodium falciparum‐infected erythrocytes |
title_sort | evidence of promiscuous endothelial binding by plasmodium falciparum‐infected erythrocytes |
topic | Special Issue on Malaria |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114535/ https://www.ncbi.nlm.nih.gov/pubmed/24444337 http://dx.doi.org/10.1111/cmi.12270 |
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