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Cerebral blood flow response to acute hypoxic hypoxia
Hypoxic hypoxia (inspiratory hypoxia) stimulates an increase in cerebral blood flow (CBF) maintaining oxygen delivery to the brain. However, this response, particularly at the tissue level, is not well characterised. This study quantifies the CBF response to acute hypoxic hypoxia in healthy subjects...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114548/ https://www.ncbi.nlm.nih.gov/pubmed/24123253 http://dx.doi.org/10.1002/nbm.3026 |
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author | Harris, Ashley D Murphy, Kevin Diaz, Claris M Saxena, Neeraj Hall, Judith E Liu, Thomas T Wise, Richard G |
author_facet | Harris, Ashley D Murphy, Kevin Diaz, Claris M Saxena, Neeraj Hall, Judith E Liu, Thomas T Wise, Richard G |
author_sort | Harris, Ashley D |
collection | PubMed |
description | Hypoxic hypoxia (inspiratory hypoxia) stimulates an increase in cerebral blood flow (CBF) maintaining oxygen delivery to the brain. However, this response, particularly at the tissue level, is not well characterised. This study quantifies the CBF response to acute hypoxic hypoxia in healthy subjects. A 20-min hypoxic (mean P(ET)o(2) = 52 mmHg) challenge was induced and controlled by dynamic end-tidal forcing whilst CBF was measured using pulsed arterial spin labelling perfusion MRI. The rate constant, temporal delay and magnitude of the CBF response were characterised using an exponential model for whole-brain and regional grey matter. Grey matter CBF increased from 76.1 mL/100 g/min (95% confidence interval (CI) of fitting: 75.5 mL/100 g/min, 76.7 mL/100 g/min) to 87.8 mL/100 g/min (95% CI: 86.7 mL/100 g/min, 89.6 mL/100 g/min) during hypoxia, and the temporal delay and rate constant for the response to hypoxia were 185 s (95% CI: 132 s, 230 s) and 0.0035 s(–1) (95% CI: 0.0019 s(–1), 0.0046 s(–1)), respectively. Recovery from hypoxia was faster with a delay of 20 s (95% CI: –38 s, 38 s) and a rate constant of 0.0069 s(–1) (95% CI: 0.0020 s(–1), 0.0103 s(–1)). R(2)*, an index of blood oxygenation obtained simultaneously with the CBF measurement, increased from 30.33 s(–1) (CI: 30.31 s(–1), 30.34 s(–1)) to 31.48 s(–1) (CI: 31.47 s(–1), 31.49 s(–1)) with hypoxia. The delay and rate constant for changes in R(2)* were 24 s (95% CI: 21 s, 26 s) and 0.0392 s(–1) (95% CI: 0.0333 s(–1), 0.045 s(–1) ), respectively, for the hypoxic response, and 12 s (95% CI: 10 s, 13 s) and 0.0921 s(–1) (95% CI: 0.0744 s(–1), 0.1098 s(–1)/) during the return to normoxia, confirming rapid changes in blood oxygenation with the end-tidal forcing system. CBF and R(2)* reactivity to hypoxia differed between subjects, but only R(2)* reactivity to hypoxia differed significantly between brain regions. © 2013 The Authors. NMR in Biomedicine published by John Wiley & Sons, Ltd. |
format | Online Article Text |
id | pubmed-4114548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BlackWell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41145482014-09-02 Cerebral blood flow response to acute hypoxic hypoxia Harris, Ashley D Murphy, Kevin Diaz, Claris M Saxena, Neeraj Hall, Judith E Liu, Thomas T Wise, Richard G NMR Biomed Research Articles Hypoxic hypoxia (inspiratory hypoxia) stimulates an increase in cerebral blood flow (CBF) maintaining oxygen delivery to the brain. However, this response, particularly at the tissue level, is not well characterised. This study quantifies the CBF response to acute hypoxic hypoxia in healthy subjects. A 20-min hypoxic (mean P(ET)o(2) = 52 mmHg) challenge was induced and controlled by dynamic end-tidal forcing whilst CBF was measured using pulsed arterial spin labelling perfusion MRI. The rate constant, temporal delay and magnitude of the CBF response were characterised using an exponential model for whole-brain and regional grey matter. Grey matter CBF increased from 76.1 mL/100 g/min (95% confidence interval (CI) of fitting: 75.5 mL/100 g/min, 76.7 mL/100 g/min) to 87.8 mL/100 g/min (95% CI: 86.7 mL/100 g/min, 89.6 mL/100 g/min) during hypoxia, and the temporal delay and rate constant for the response to hypoxia were 185 s (95% CI: 132 s, 230 s) and 0.0035 s(–1) (95% CI: 0.0019 s(–1), 0.0046 s(–1)), respectively. Recovery from hypoxia was faster with a delay of 20 s (95% CI: –38 s, 38 s) and a rate constant of 0.0069 s(–1) (95% CI: 0.0020 s(–1), 0.0103 s(–1)). R(2)*, an index of blood oxygenation obtained simultaneously with the CBF measurement, increased from 30.33 s(–1) (CI: 30.31 s(–1), 30.34 s(–1)) to 31.48 s(–1) (CI: 31.47 s(–1), 31.49 s(–1)) with hypoxia. The delay and rate constant for changes in R(2)* were 24 s (95% CI: 21 s, 26 s) and 0.0392 s(–1) (95% CI: 0.0333 s(–1), 0.045 s(–1) ), respectively, for the hypoxic response, and 12 s (95% CI: 10 s, 13 s) and 0.0921 s(–1) (95% CI: 0.0744 s(–1), 0.1098 s(–1)/) during the return to normoxia, confirming rapid changes in blood oxygenation with the end-tidal forcing system. CBF and R(2)* reactivity to hypoxia differed between subjects, but only R(2)* reactivity to hypoxia differed significantly between brain regions. © 2013 The Authors. NMR in Biomedicine published by John Wiley & Sons, Ltd. BlackWell Publishing Ltd 2013-12 2013-10-07 /pmc/articles/PMC4114548/ /pubmed/24123253 http://dx.doi.org/10.1002/nbm.3026 Text en © 2013 The Authors. NMR in Biomedicine published by John Wiley & Sons, Ltd. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Harris, Ashley D Murphy, Kevin Diaz, Claris M Saxena, Neeraj Hall, Judith E Liu, Thomas T Wise, Richard G Cerebral blood flow response to acute hypoxic hypoxia |
title | Cerebral blood flow response to acute hypoxic hypoxia |
title_full | Cerebral blood flow response to acute hypoxic hypoxia |
title_fullStr | Cerebral blood flow response to acute hypoxic hypoxia |
title_full_unstemmed | Cerebral blood flow response to acute hypoxic hypoxia |
title_short | Cerebral blood flow response to acute hypoxic hypoxia |
title_sort | cerebral blood flow response to acute hypoxic hypoxia |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114548/ https://www.ncbi.nlm.nih.gov/pubmed/24123253 http://dx.doi.org/10.1002/nbm.3026 |
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