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Sonic Hedgehog-Gli1 Signaling Pathway Regulates the Epithelial Mesenchymal Transition (EMT) by Mediating a New Target Gene, S100A4, in Pancreatic Cancer Cells

AIMS: The hedgehog signaling pathway plays an important role in EMT of pancreatic cancer cells, but the precise mechanisms remain elusive. Because S100A4 as a key EMT moleculer marker was found to be upregulated upon Gli1 in pancreatic cancer cells, we focused on the relationship between Shh-Gli1 si...

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Detalles Bibliográficos
Autores principales:	Xu, Xuanfu, Su, Bin, Xie, Chuangao, Wei, Shumei, Zhou, Yingqun, Liu, Hua, Dai, Weiqi, Cheng, Ping, Wang, Fan, Xu, Xiaorong, Guo, Chuanyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114558/ https://www.ncbi.nlm.nih.gov/pubmed/25072505 http://dx.doi.org/10.1371/journal.pone.0096441

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