Cargando…

Expression of Kin17 promotes the proliferation of hepatocellular carcinoma cells in vitro and in vivo

Kin17 protein is ubiquitously expressed in mammals and is correlated with vital biological functions. However, little is known about the role of Kin17 in the proliferation of hepatocellular carcinoma cells. The aim of the present study was to investigate whether the upregulation of Kin17 can promote...

Descripción completa

Detalles Bibliográficos
Autores principales: KOU, WEI-ZHENG, XU, SU-LING, WANG, YING, WANG, LI-WEI, WANG, LEI, CHAI, XIAO-YAN, HUA, QIN-LIANG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114639/
https://www.ncbi.nlm.nih.gov/pubmed/25120685
http://dx.doi.org/10.3892/ol.2014.2244
_version_ 1782328466728812544
author KOU, WEI-ZHENG
XU, SU-LING
WANG, YING
WANG, LI-WEI
WANG, LEI
CHAI, XIAO-YAN
HUA, QIN-LIANG
author_facet KOU, WEI-ZHENG
XU, SU-LING
WANG, YING
WANG, LI-WEI
WANG, LEI
CHAI, XIAO-YAN
HUA, QIN-LIANG
author_sort KOU, WEI-ZHENG
collection PubMed
description Kin17 protein is ubiquitously expressed in mammals and is correlated with vital biological functions. However, little is known about the role of Kin17 in the proliferation of hepatocellular carcinoma cells. The aim of the present study was to investigate whether the upregulation of Kin17 can promote the growth of hepatocellular carcinoma cells. A series of assays was performed to study the effect of Kin17 in the proliferation of hepatocellular carcinoma cells in vitro and in vivo. The western blotting results revealed that Kin17 expression was increased in hepatocellular carcinoma tissues compared with that of the corresponding normal tissues. Moreover, ectopic upregulation of Kin17 expression promoted the growth of hepatocellular carcinoma cells in vitro and in vivo. These results indicated that Kin17 is involved in the tumorigenesis of hepatocellular carcinoma, and that Kin17 has the potential to serve as a therapeutic target for hepatocellular carcinoma.
format Online
Article
Text
id pubmed-4114639
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-41146392014-08-12 Expression of Kin17 promotes the proliferation of hepatocellular carcinoma cells in vitro and in vivo KOU, WEI-ZHENG XU, SU-LING WANG, YING WANG, LI-WEI WANG, LEI CHAI, XIAO-YAN HUA, QIN-LIANG Oncol Lett Articles Kin17 protein is ubiquitously expressed in mammals and is correlated with vital biological functions. However, little is known about the role of Kin17 in the proliferation of hepatocellular carcinoma cells. The aim of the present study was to investigate whether the upregulation of Kin17 can promote the growth of hepatocellular carcinoma cells. A series of assays was performed to study the effect of Kin17 in the proliferation of hepatocellular carcinoma cells in vitro and in vivo. The western blotting results revealed that Kin17 expression was increased in hepatocellular carcinoma tissues compared with that of the corresponding normal tissues. Moreover, ectopic upregulation of Kin17 expression promoted the growth of hepatocellular carcinoma cells in vitro and in vivo. These results indicated that Kin17 is involved in the tumorigenesis of hepatocellular carcinoma, and that Kin17 has the potential to serve as a therapeutic target for hepatocellular carcinoma. D.A. Spandidos 2014-09 2014-06-12 /pmc/articles/PMC4114639/ /pubmed/25120685 http://dx.doi.org/10.3892/ol.2014.2244 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
KOU, WEI-ZHENG
XU, SU-LING
WANG, YING
WANG, LI-WEI
WANG, LEI
CHAI, XIAO-YAN
HUA, QIN-LIANG
Expression of Kin17 promotes the proliferation of hepatocellular carcinoma cells in vitro and in vivo
title Expression of Kin17 promotes the proliferation of hepatocellular carcinoma cells in vitro and in vivo
title_full Expression of Kin17 promotes the proliferation of hepatocellular carcinoma cells in vitro and in vivo
title_fullStr Expression of Kin17 promotes the proliferation of hepatocellular carcinoma cells in vitro and in vivo
title_full_unstemmed Expression of Kin17 promotes the proliferation of hepatocellular carcinoma cells in vitro and in vivo
title_short Expression of Kin17 promotes the proliferation of hepatocellular carcinoma cells in vitro and in vivo
title_sort expression of kin17 promotes the proliferation of hepatocellular carcinoma cells in vitro and in vivo
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114639/
https://www.ncbi.nlm.nih.gov/pubmed/25120685
http://dx.doi.org/10.3892/ol.2014.2244
work_keys_str_mv AT kouweizheng expressionofkin17promotestheproliferationofhepatocellularcarcinomacellsinvitroandinvivo
AT xusuling expressionofkin17promotestheproliferationofhepatocellularcarcinomacellsinvitroandinvivo
AT wangying expressionofkin17promotestheproliferationofhepatocellularcarcinomacellsinvitroandinvivo
AT wangliwei expressionofkin17promotestheproliferationofhepatocellularcarcinomacellsinvitroandinvivo
AT wanglei expressionofkin17promotestheproliferationofhepatocellularcarcinomacellsinvitroandinvivo
AT chaixiaoyan expressionofkin17promotestheproliferationofhepatocellularcarcinomacellsinvitroandinvivo
AT huaqinliang expressionofkin17promotestheproliferationofhepatocellularcarcinomacellsinvitroandinvivo