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Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging
Determination of cathepsin D (Cat D) concentration in serum and urine may be useful in the diagnosis of bladder cancer. The present study included 54 healthy patients and 68 patients with bladder cancer, confirmed by transurethral resection or cystectomy. Cat D concentration was determined using a s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114644/ https://www.ncbi.nlm.nih.gov/pubmed/25120717 http://dx.doi.org/10.3892/ol.2014.2250 |
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author | GORODKIEWICZ, EWA GUSZCZ, TOMASZ ROSZKOWSKA-JAKIMIEC, WIESLAWA KOZŁOWSKI, ROBERT |
author_facet | GORODKIEWICZ, EWA GUSZCZ, TOMASZ ROSZKOWSKA-JAKIMIEC, WIESLAWA KOZŁOWSKI, ROBERT |
author_sort | GORODKIEWICZ, EWA |
collection | PubMed |
description | Determination of cathepsin D (Cat D) concentration in serum and urine may be useful in the diagnosis of bladder cancer. The present study included 54 healthy patients and 68 patients with bladder cancer, confirmed by transurethral resection or cystectomy. Cat D concentration was determined using a surface plasmon resonance imaging biosensor. Cat D concentration in the serum of bladder cancer patients was within the range of 1.3–5.59 ng/ml, while for healthy donors it was within the range of 0.28–0.52 ng/ml. In urine, the Cat D concentration of bladder cancer patients was within the range of 1.35–7.14 ng/ml, while for healthy donors it was within the range of 0.32–0.68 ng/ml. Cat D concentration may represent an efficient tumor marker, as its concentration in the serum and urine of transitional cell carcinoma patients is extremely high when compared with healthy subjects. |
format | Online Article Text |
id | pubmed-4114644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-41146442014-08-12 Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging GORODKIEWICZ, EWA GUSZCZ, TOMASZ ROSZKOWSKA-JAKIMIEC, WIESLAWA KOZŁOWSKI, ROBERT Oncol Lett Articles Determination of cathepsin D (Cat D) concentration in serum and urine may be useful in the diagnosis of bladder cancer. The present study included 54 healthy patients and 68 patients with bladder cancer, confirmed by transurethral resection or cystectomy. Cat D concentration was determined using a surface plasmon resonance imaging biosensor. Cat D concentration in the serum of bladder cancer patients was within the range of 1.3–5.59 ng/ml, while for healthy donors it was within the range of 0.28–0.52 ng/ml. In urine, the Cat D concentration of bladder cancer patients was within the range of 1.35–7.14 ng/ml, while for healthy donors it was within the range of 0.32–0.68 ng/ml. Cat D concentration may represent an efficient tumor marker, as its concentration in the serum and urine of transitional cell carcinoma patients is extremely high when compared with healthy subjects. D.A. Spandidos 2014-09 2014-06-12 /pmc/articles/PMC4114644/ /pubmed/25120717 http://dx.doi.org/10.3892/ol.2014.2250 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles GORODKIEWICZ, EWA GUSZCZ, TOMASZ ROSZKOWSKA-JAKIMIEC, WIESLAWA KOZŁOWSKI, ROBERT Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging |
title | Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging |
title_full | Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging |
title_fullStr | Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging |
title_full_unstemmed | Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging |
title_short | Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging |
title_sort | cathepsin d serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114644/ https://www.ncbi.nlm.nih.gov/pubmed/25120717 http://dx.doi.org/10.3892/ol.2014.2250 |
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