Cargando…
Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report
At present, only eight cases of tracheal adenoid cystic carcinomas (ACCs) mimicking thyroid tumors have been reported. Since there are no guidelines available regarding their diagnosis and treatment, they present a significant clinical challenge. In the present study, patient treatment was analyzed...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114646/ https://www.ncbi.nlm.nih.gov/pubmed/25120714 http://dx.doi.org/10.3892/ol.2014.2282 |
_version_ | 1782328468089864192 |
---|---|
author | KUKWA, WOJCIECH KORZEŃ, PIOTR WOJTOWICZ, PIOTR SOBCZYK, GRZEGORZ KIPRIAN, DOROTA KAWECKI, ANDRZEJ KUKWA, ANDRZEJ KRZESKI, ANTONI SZCZYLIK, CEZARY CZARNECKA, ANNA M. |
author_facet | KUKWA, WOJCIECH KORZEŃ, PIOTR WOJTOWICZ, PIOTR SOBCZYK, GRZEGORZ KIPRIAN, DOROTA KAWECKI, ANDRZEJ KUKWA, ANDRZEJ KRZESKI, ANTONI SZCZYLIK, CEZARY CZARNECKA, ANNA M. |
author_sort | KUKWA, WOJCIECH |
collection | PubMed |
description | At present, only eight cases of tracheal adenoid cystic carcinomas (ACCs) mimicking thyroid tumors have been reported. Since there are no guidelines available regarding their diagnosis and treatment, they present a significant clinical challenge. In the present study, patient treatment was analyzed to deliver the first concise summary of treatment options in patients with ACC mimicking a thyroid tumor. In addition, all available data regarding molecular abnormalities of this disease have been discussed. The current study presents a case of a 17-year-old patient with a tracheal ACC mimicking a thyroid tumor. The patient was diagnosed in 2007 with a pathological mass between the left lobe of the thyroid and the trachea, and underwent surgery and radiotherapy. In 2010, multiple lesions in the lungs were diagnosed and pulmonary metastasectomy was performed. Following surgery, the patient has been disease-free for almost 30 months. Thyroid tumor biopsy may reveal ACCs. This pathological report requires further investigation of the head and neck in order to confirm if the disease is of tracheal origin. Patients may present with a neck swelling, hoarseness of voice or dysphagia. Surgery must be considered as first-line therapy for all patients with local disease as it may be curative. For palliative treatment chemoradiotherapy based on cisplatin may be effective. The identification of cytogenetics, tumor suppressor genes, oncogenes, epigenetic alterations and mitochondrial abnormalities specific for ACCs is critical to the development of targeted therapies. Thus far, large studies have only reported the transcriptional activator Myb and mammalian target of rapamycin signaling pathway to be disrupted in ACCs. |
format | Online Article Text |
id | pubmed-4114646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-41146462014-08-12 Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report KUKWA, WOJCIECH KORZEŃ, PIOTR WOJTOWICZ, PIOTR SOBCZYK, GRZEGORZ KIPRIAN, DOROTA KAWECKI, ANDRZEJ KUKWA, ANDRZEJ KRZESKI, ANTONI SZCZYLIK, CEZARY CZARNECKA, ANNA M. Oncol Lett Articles At present, only eight cases of tracheal adenoid cystic carcinomas (ACCs) mimicking thyroid tumors have been reported. Since there are no guidelines available regarding their diagnosis and treatment, they present a significant clinical challenge. In the present study, patient treatment was analyzed to deliver the first concise summary of treatment options in patients with ACC mimicking a thyroid tumor. In addition, all available data regarding molecular abnormalities of this disease have been discussed. The current study presents a case of a 17-year-old patient with a tracheal ACC mimicking a thyroid tumor. The patient was diagnosed in 2007 with a pathological mass between the left lobe of the thyroid and the trachea, and underwent surgery and radiotherapy. In 2010, multiple lesions in the lungs were diagnosed and pulmonary metastasectomy was performed. Following surgery, the patient has been disease-free for almost 30 months. Thyroid tumor biopsy may reveal ACCs. This pathological report requires further investigation of the head and neck in order to confirm if the disease is of tracheal origin. Patients may present with a neck swelling, hoarseness of voice or dysphagia. Surgery must be considered as first-line therapy for all patients with local disease as it may be curative. For palliative treatment chemoradiotherapy based on cisplatin may be effective. The identification of cytogenetics, tumor suppressor genes, oncogenes, epigenetic alterations and mitochondrial abnormalities specific for ACCs is critical to the development of targeted therapies. Thus far, large studies have only reported the transcriptional activator Myb and mammalian target of rapamycin signaling pathway to be disrupted in ACCs. D.A. Spandidos 2014-09 2014-06-25 /pmc/articles/PMC4114646/ /pubmed/25120714 http://dx.doi.org/10.3892/ol.2014.2282 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles KUKWA, WOJCIECH KORZEŃ, PIOTR WOJTOWICZ, PIOTR SOBCZYK, GRZEGORZ KIPRIAN, DOROTA KAWECKI, ANDRZEJ KUKWA, ANDRZEJ KRZESKI, ANTONI SZCZYLIK, CEZARY CZARNECKA, ANNA M. Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report |
title | Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report |
title_full | Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report |
title_fullStr | Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report |
title_full_unstemmed | Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report |
title_short | Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report |
title_sort | tracheal adenoid cystic carcinoma mimicking a thyroid tumor: a case report |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114646/ https://www.ncbi.nlm.nih.gov/pubmed/25120714 http://dx.doi.org/10.3892/ol.2014.2282 |
work_keys_str_mv | AT kukwawojciech trachealadenoidcysticcarcinomamimickingathyroidtumoracasereport AT korzenpiotr trachealadenoidcysticcarcinomamimickingathyroidtumoracasereport AT wojtowiczpiotr trachealadenoidcysticcarcinomamimickingathyroidtumoracasereport AT sobczykgrzegorz trachealadenoidcysticcarcinomamimickingathyroidtumoracasereport AT kipriandorota trachealadenoidcysticcarcinomamimickingathyroidtumoracasereport AT kaweckiandrzej trachealadenoidcysticcarcinomamimickingathyroidtumoracasereport AT kukwaandrzej trachealadenoidcysticcarcinomamimickingathyroidtumoracasereport AT krzeskiantoni trachealadenoidcysticcarcinomamimickingathyroidtumoracasereport AT szczylikcezary trachealadenoidcysticcarcinomamimickingathyroidtumoracasereport AT czarneckaannam trachealadenoidcysticcarcinomamimickingathyroidtumoracasereport |