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Periductal stromal sarcoma of the breast: A case report and review of the literature

Periductal stromal sarcoma (PSS), spindle and epithelioid types, is a rare subtype of malignant fibroepithelial tumor. The morphological characteristics of this neoplasm are different from phyllodes tumor and stromal sarcoma. PSS exhibits biphasic histology with benign ductal elements and a sarcomat...

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Autores principales: LAN, YANDAN, ZHU, JIA, LIU, JIANLUN, YANG, HUAWEI, JIANG, YI, WEI, WEI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114652/
https://www.ncbi.nlm.nih.gov/pubmed/25120682
http://dx.doi.org/10.3892/ol.2014.2294
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author LAN, YANDAN
ZHU, JIA
LIU, JIANLUN
YANG, HUAWEI
JIANG, YI
WEI, WEI
author_facet LAN, YANDAN
ZHU, JIA
LIU, JIANLUN
YANG, HUAWEI
JIANG, YI
WEI, WEI
author_sort LAN, YANDAN
collection PubMed
description Periductal stromal sarcoma (PSS), spindle and epithelioid types, is a rare subtype of malignant fibroepithelial tumor. The morphological characteristics of this neoplasm are different from phyllodes tumor and stromal sarcoma. PSS exhibits biphasic histology with benign ductal elements and a sarcomatous stroma composed of spindle cells and lacking phyllodes tumor architecture. The therapeutic management of PSS is based on wide surgery with free margins, and adjuvant therapies are not required. To the best of our knowledge, the recurrence of PSS in ≤5 months has not been reported in the literature to date. This report describes a 43-year-old woman who presented to our hospital with a recurrence of nodules in the left breast. The patient had undergone lumpectomy at a different hospital 5 months previously, and a diagnosis of phyllodes tumor was pathologically confirmed. On presentation at our hospital, the patient underwent a second lumpectomy. Histological examination revealed PSS and the patient underwent a simple mastectomy of the left breast with no adjuvant treatment (such as chemotherapy or radiotherapy). After 9 months of close follow-up examinations, no recurrence was observed. PSS is an extremely rare disease with low-grade sarcomatous behavior, which may evolve into a phyllodes tumor or an entity of breast cancer. Therefore, frequent follow-up examinations are required.
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spelling pubmed-41146522014-08-12 Periductal stromal sarcoma of the breast: A case report and review of the literature LAN, YANDAN ZHU, JIA LIU, JIANLUN YANG, HUAWEI JIANG, YI WEI, WEI Oncol Lett Articles Periductal stromal sarcoma (PSS), spindle and epithelioid types, is a rare subtype of malignant fibroepithelial tumor. The morphological characteristics of this neoplasm are different from phyllodes tumor and stromal sarcoma. PSS exhibits biphasic histology with benign ductal elements and a sarcomatous stroma composed of spindle cells and lacking phyllodes tumor architecture. The therapeutic management of PSS is based on wide surgery with free margins, and adjuvant therapies are not required. To the best of our knowledge, the recurrence of PSS in ≤5 months has not been reported in the literature to date. This report describes a 43-year-old woman who presented to our hospital with a recurrence of nodules in the left breast. The patient had undergone lumpectomy at a different hospital 5 months previously, and a diagnosis of phyllodes tumor was pathologically confirmed. On presentation at our hospital, the patient underwent a second lumpectomy. Histological examination revealed PSS and the patient underwent a simple mastectomy of the left breast with no adjuvant treatment (such as chemotherapy or radiotherapy). After 9 months of close follow-up examinations, no recurrence was observed. PSS is an extremely rare disease with low-grade sarcomatous behavior, which may evolve into a phyllodes tumor or an entity of breast cancer. Therefore, frequent follow-up examinations are required. D.A. Spandidos 2014-09 2014-06-27 /pmc/articles/PMC4114652/ /pubmed/25120682 http://dx.doi.org/10.3892/ol.2014.2294 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
LAN, YANDAN
ZHU, JIA
LIU, JIANLUN
YANG, HUAWEI
JIANG, YI
WEI, WEI
Periductal stromal sarcoma of the breast: A case report and review of the literature
title Periductal stromal sarcoma of the breast: A case report and review of the literature
title_full Periductal stromal sarcoma of the breast: A case report and review of the literature
title_fullStr Periductal stromal sarcoma of the breast: A case report and review of the literature
title_full_unstemmed Periductal stromal sarcoma of the breast: A case report and review of the literature
title_short Periductal stromal sarcoma of the breast: A case report and review of the literature
title_sort periductal stromal sarcoma of the breast: a case report and review of the literature
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114652/
https://www.ncbi.nlm.nih.gov/pubmed/25120682
http://dx.doi.org/10.3892/ol.2014.2294
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