Transcript assisted phosphodiester bond hydrolysis by eukaryotic RNA polymerase II

Hydrolysis of the phosphodiester bonds of the transcript by bacterial RNA polymerase is assisted by 3′NMP of the RNA. Here we provide evidence that this mechanism is also involved in RNA cleavage by eukaryotic RNA polymerase II, suggesting that transcript assisted hydrolysis has emerged before diver...

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Detalles Bibliográficos
Autores principales: Nielsen, Soren, Zenkin, Nikolay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Point of View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114657/
https://www.ncbi.nlm.nih.gov/pubmed/24270513
http://dx.doi.org/10.4161/trns.27062
Descripción
Sumario:Hydrolysis of the phosphodiester bonds of the transcript by bacterial RNA polymerase is assisted by 3′NMP of the RNA. Here we provide evidence that this mechanism is also involved in RNA cleavage by eukaryotic RNA polymerase II, suggesting that transcript assisted hydrolysis has emerged before divergence of bacteria and archaea/eukaryotes.

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