Transcript assisted phosphodiester bond hydrolysis by eukaryotic RNA polymerase II

Hydrolysis of the phosphodiester bonds of the transcript by bacterial RNA polymerase is assisted by 3′NMP of the RNA. Here we provide evidence that this mechanism is also involved in RNA cleavage by eukaryotic RNA polymerase II, suggesting that transcript assisted hydrolysis has emerged before diver...

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Detalles Bibliográficos
Autores principales: Nielsen, Soren, Zenkin, Nikolay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Point of View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114657/
https://www.ncbi.nlm.nih.gov/pubmed/24270513
http://dx.doi.org/10.4161/trns.27062
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author Nielsen, Soren
Zenkin, Nikolay
author_facet Nielsen, Soren
Zenkin, Nikolay
author_sort Nielsen, Soren
collection PubMed
description Hydrolysis of the phosphodiester bonds of the transcript by bacterial RNA polymerase is assisted by 3′NMP of the RNA. Here we provide evidence that this mechanism is also involved in RNA cleavage by eukaryotic RNA polymerase II, suggesting that transcript assisted hydrolysis has emerged before divergence of bacteria and archaea/eukaryotes.
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spelling pubmed-41146572014-07-30 Transcript assisted phosphodiester bond hydrolysis by eukaryotic RNA polymerase II Nielsen, Soren Zenkin, Nikolay Transcription Point of View Hydrolysis of the phosphodiester bonds of the transcript by bacterial RNA polymerase is assisted by 3′NMP of the RNA. Here we provide evidence that this mechanism is also involved in RNA cleavage by eukaryotic RNA polymerase II, suggesting that transcript assisted hydrolysis has emerged before divergence of bacteria and archaea/eukaryotes. Landes Bioscience 2013-09-01 2013-11-08 /pmc/articles/PMC4114657/ /pubmed/24270513 http://dx.doi.org/10.4161/trns.27062 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Point of View
Nielsen, Soren
Zenkin, Nikolay
Transcript assisted phosphodiester bond hydrolysis by eukaryotic RNA polymerase II
title Transcript assisted phosphodiester bond hydrolysis by eukaryotic RNA polymerase II
title_full Transcript assisted phosphodiester bond hydrolysis by eukaryotic RNA polymerase II
title_fullStr Transcript assisted phosphodiester bond hydrolysis by eukaryotic RNA polymerase II
title_full_unstemmed Transcript assisted phosphodiester bond hydrolysis by eukaryotic RNA polymerase II
title_short Transcript assisted phosphodiester bond hydrolysis by eukaryotic RNA polymerase II
title_sort transcript assisted phosphodiester bond hydrolysis by eukaryotic rna polymerase ii
topic Point of View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114657/
https://www.ncbi.nlm.nih.gov/pubmed/24270513
http://dx.doi.org/10.4161/trns.27062
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AT zenkinnikolay transcriptassistedphosphodiesterbondhydrolysisbyeukaryoticrnapolymeraseii

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