The Allosteric HIV-1 Integrase Inhibitor BI-D Affects Virion Maturation but Does Not Influence Packaging of a Functional RNA Genome

The viral integrase (IN) is an essential protein for HIV-1 replication. IN inserts the viral dsDNA into the host chromosome, thereby aided by the cellular co-factor LEDGF/p75. Recently a new class of integrase inhibitors was described: allosteric IN inhibitors (ALLINIs). Although designed to interfe...

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Detalles Bibliográficos
Autores principales: van Bel, Nikki, van der Velden, Yme, Bonnard, Damien, Le Rouzic, Erwann, Das, Atze T., Benarous, Richard, Berkhout, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114784/
https://www.ncbi.nlm.nih.gov/pubmed/25072705
http://dx.doi.org/10.1371/journal.pone.0103552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114784/
https://www.ncbi.nlm.nih.gov/pubmed/25072705
http://dx.doi.org/10.1371/journal.pone.0103552

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