Cargando…
The Allosteric HIV-1 Integrase Inhibitor BI-D Affects Virion Maturation but Does Not Influence Packaging of a Functional RNA Genome
The viral integrase (IN) is an essential protein for HIV-1 replication. IN inserts the viral dsDNA into the host chromosome, thereby aided by the cellular co-factor LEDGF/p75. Recently a new class of integrase inhibitors was described: allosteric IN inhibitors (ALLINIs). Although designed to interfe...
Autores principales: | van Bel, Nikki, van der Velden, Yme, Bonnard, Damien, Le Rouzic, Erwann, Das, Atze T., Benarous, Richard, Berkhout, Ben |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114784/ https://www.ncbi.nlm.nih.gov/pubmed/25072705 http://dx.doi.org/10.1371/journal.pone.0103552 |
Ejemplares similares
-
The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity
por: Amadori, Céline, et al.
Publicado: (2017) -
Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase
por: Bonnard, Damien, et al.
Publicado: (2023) -
Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage
por: Le Rouzic, Erwann, et al.
Publicado: (2013) -
Sequences up- and down-stream of the DIS hairpin are important for HIV-1 replication
por: van Bel, Nikki, et al.
Publicado: (2011) -
In vivo SELEX of single-stranded domains in the HIV-1 leader RNA
por: van Bel, Nikki, et al.
Publicado: (2013)