Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer

Triple negative breast cancer (TNBC) is a highly aggressive form of breast cancer resistant to many common treatments. In this study, we compared the effects of 12 phytochemical drugs on four cancer cell lines, and noticed that Cucurbitacin E (CuE) significantly inhibited TNBC cell growth by inducin...

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Detalles Bibliográficos
Autores principales: Kong, Yanjie, Chen, Jianchao, Zhou, Zhongmei, Xia, Houjun, Qiu, Ming-Hua, Chen, Ceshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114842/
https://www.ncbi.nlm.nih.gov/pubmed/25072848
http://dx.doi.org/10.1371/journal.pone.0103760
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author Kong, Yanjie
Chen, Jianchao
Zhou, Zhongmei
Xia, Houjun
Qiu, Ming-Hua
Chen, Ceshi
author_facet Kong, Yanjie
Chen, Jianchao
Zhou, Zhongmei
Xia, Houjun
Qiu, Ming-Hua
Chen, Ceshi
author_sort Kong, Yanjie
collection PubMed
description Triple negative breast cancer (TNBC) is a highly aggressive form of breast cancer resistant to many common treatments. In this study, we compared the effects of 12 phytochemical drugs on four cancer cell lines, and noticed that Cucurbitacin E (CuE) significantly inhibited TNBC cell growth by inducing cell cycle G2/M phase arrest and apoptosis. CuE reduced expression of Cyclin D1, Survivin, XIAP, Bcl2, and Mcl-1 in MDA-MB-468 and SW527, and within MDA-MB-468, CuE significantly increased activation of JNK and inhibited activation of AKT and ERK. Collectively, these results suggest that CuE may be a viable compound for developing novel TNBC therapeutics.
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spelling pubmed-41148422014-08-04 Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer Kong, Yanjie Chen, Jianchao Zhou, Zhongmei Xia, Houjun Qiu, Ming-Hua Chen, Ceshi PLoS One Research Article Triple negative breast cancer (TNBC) is a highly aggressive form of breast cancer resistant to many common treatments. In this study, we compared the effects of 12 phytochemical drugs on four cancer cell lines, and noticed that Cucurbitacin E (CuE) significantly inhibited TNBC cell growth by inducing cell cycle G2/M phase arrest and apoptosis. CuE reduced expression of Cyclin D1, Survivin, XIAP, Bcl2, and Mcl-1 in MDA-MB-468 and SW527, and within MDA-MB-468, CuE significantly increased activation of JNK and inhibited activation of AKT and ERK. Collectively, these results suggest that CuE may be a viable compound for developing novel TNBC therapeutics. Public Library of Science 2014-07-29 /pmc/articles/PMC4114842/ /pubmed/25072848 http://dx.doi.org/10.1371/journal.pone.0103760 Text en © 2014 Kong et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kong, Yanjie
Chen, Jianchao
Zhou, Zhongmei
Xia, Houjun
Qiu, Ming-Hua
Chen, Ceshi
Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer
title Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer
title_full Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer
title_fullStr Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer
title_full_unstemmed Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer
title_short Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer
title_sort cucurbitacin e induces cell cycle g2/m phase arrest and apoptosis in triple negative breast cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114842/
https://www.ncbi.nlm.nih.gov/pubmed/25072848
http://dx.doi.org/10.1371/journal.pone.0103760
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