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Mesenchymal stem cells transplantation for neuroprotection in preterm infants with severe intraventricular hemorrhage
Severe intraventricular hemorrhaging (IVH) in premature infants and subsequent posthemorrhagic hydrocephalus (PHH) causes significant mortality and life-long neurological complications, including seizures, cerebral palsy, and developmental retardation. However, there are currently no effective thera...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Pediatric Society
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115065/ https://www.ncbi.nlm.nih.gov/pubmed/25076969 http://dx.doi.org/10.3345/kjp.2014.57.6.251 |
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author | Ahn, So Yoon Chang, Yun Sil Park, Won Soon |
author_facet | Ahn, So Yoon Chang, Yun Sil Park, Won Soon |
author_sort | Ahn, So Yoon |
collection | PubMed |
description | Severe intraventricular hemorrhaging (IVH) in premature infants and subsequent posthemorrhagic hydrocephalus (PHH) causes significant mortality and life-long neurological complications, including seizures, cerebral palsy, and developmental retardation. However, there are currently no effective therapies for neonatal IVH. The pathogenesis of PHH has been mainly explained by inflammation within the subarachnoid spaces due to the hemolysis of extravasated blood after IVH. Obliterative arachnoiditis, induced by inflammatory responses, impairs cerebrospinal fluid (CSF) resorption and subsequently leads to the development of PHH with ensuing brain damage. Increasing evidence has demonstrated potent immunomodulating abilities of mesenchymal stem cells (MSCs) in various brain injury models. Recent reports of MSC transplantation in an IVH model of newborn rats demonstrated that intraventricular transplantation of MSCs downregulated the inflammatory cytokines in CSF and attenuated progressive PHH. In addition, MSC transplantation mitigated the brain damages that ensue after IVH and PHH, including reactive gliosis, cell death, delayed myelination, and impaired behavioral functions. These findings suggest that MSCs are promising therapeutic agents for neuroprotection in preterm infants with severe IVH. |
format | Online Article Text |
id | pubmed-4115065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Korean Pediatric Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-41150652014-07-30 Mesenchymal stem cells transplantation for neuroprotection in preterm infants with severe intraventricular hemorrhage Ahn, So Yoon Chang, Yun Sil Park, Won Soon Korean J Pediatr Review Article Severe intraventricular hemorrhaging (IVH) in premature infants and subsequent posthemorrhagic hydrocephalus (PHH) causes significant mortality and life-long neurological complications, including seizures, cerebral palsy, and developmental retardation. However, there are currently no effective therapies for neonatal IVH. The pathogenesis of PHH has been mainly explained by inflammation within the subarachnoid spaces due to the hemolysis of extravasated blood after IVH. Obliterative arachnoiditis, induced by inflammatory responses, impairs cerebrospinal fluid (CSF) resorption and subsequently leads to the development of PHH with ensuing brain damage. Increasing evidence has demonstrated potent immunomodulating abilities of mesenchymal stem cells (MSCs) in various brain injury models. Recent reports of MSC transplantation in an IVH model of newborn rats demonstrated that intraventricular transplantation of MSCs downregulated the inflammatory cytokines in CSF and attenuated progressive PHH. In addition, MSC transplantation mitigated the brain damages that ensue after IVH and PHH, including reactive gliosis, cell death, delayed myelination, and impaired behavioral functions. These findings suggest that MSCs are promising therapeutic agents for neuroprotection in preterm infants with severe IVH. The Korean Pediatric Society 2014-06 2014-06-30 /pmc/articles/PMC4115065/ /pubmed/25076969 http://dx.doi.org/10.3345/kjp.2014.57.6.251 Text en Copyright © 2014 by The Korean Pediatric Society http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ahn, So Yoon Chang, Yun Sil Park, Won Soon Mesenchymal stem cells transplantation for neuroprotection in preterm infants with severe intraventricular hemorrhage |
title | Mesenchymal stem cells transplantation for neuroprotection in preterm infants with severe intraventricular hemorrhage |
title_full | Mesenchymal stem cells transplantation for neuroprotection in preterm infants with severe intraventricular hemorrhage |
title_fullStr | Mesenchymal stem cells transplantation for neuroprotection in preterm infants with severe intraventricular hemorrhage |
title_full_unstemmed | Mesenchymal stem cells transplantation for neuroprotection in preterm infants with severe intraventricular hemorrhage |
title_short | Mesenchymal stem cells transplantation for neuroprotection in preterm infants with severe intraventricular hemorrhage |
title_sort | mesenchymal stem cells transplantation for neuroprotection in preterm infants with severe intraventricular hemorrhage |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115065/ https://www.ncbi.nlm.nih.gov/pubmed/25076969 http://dx.doi.org/10.3345/kjp.2014.57.6.251 |
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