Depletion of 14-3-3γ reduces the surface expression of Transient Receptor Potential Melastatin 4b (TRPM4b) Channels and attenuates TRPM4b-mediated glutamate-induced neuronal cell death

BACKGROUND: TRPM4 channels are Ca(2+)-activated nonselective cation channels which are deeply involved in physiological and pathological conditions. However, their trafficking mechanism and binding partners are still elusive. RESULTS: We have found the 14-3-3γ as a binding partner for TRPM4b using i...

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Detalles Bibliográficos
Autores principales: Cho, Chang-Hoon, Kim, Eunju, Lee, Young-Sun, Yarishkin, Oleg, Yoo, Jae Cheal, Park, Jae-Yong, Hong, Seong-Geun, Hwang, Eun Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115172/
https://www.ncbi.nlm.nih.gov/pubmed/25047048
http://dx.doi.org/10.1186/s13041-014-0052-3

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