A Small Molecule Agonist THIQ as a Novel Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants

Although mutations in the melanocortin-4 receptor (MC4R) gene cause severe early-onset obesity, we still do not have effective approaches to correct the defects of these mutations. Several antagonists have been identified as pharmacoperones of the MC4R whereas no agonist of the MC4R has been reporte...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Hui, Tao, Ya-Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115193/
https://www.ncbi.nlm.nih.gov/pubmed/25076858
http://dx.doi.org/10.7150/ijbs.9625

Ejemplares similares