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Plasmodium falciparum parasites lacking histidine-rich protein 2 and 3: a review and recommendations for accurate reporting

Malaria rapid diagnostic tests (RDTs) play a critical role in malaria case management, surveillance and case investigations. Test performance is largely determined by design and quality characteristics, such as detection sensitivity, specificity, and thermal stability. However, parasite characterist...

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Detalles Bibliográficos
Autores principales: Cheng, Qin, Gatton, Michelle L, Barnwell, John, Chiodini, Peter, McCarthy, James, Bell, David, Cunningham, Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115471/
https://www.ncbi.nlm.nih.gov/pubmed/25052298
http://dx.doi.org/10.1186/1475-2875-13-283
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author Cheng, Qin
Gatton, Michelle L
Barnwell, John
Chiodini, Peter
McCarthy, James
Bell, David
Cunningham, Jane
author_facet Cheng, Qin
Gatton, Michelle L
Barnwell, John
Chiodini, Peter
McCarthy, James
Bell, David
Cunningham, Jane
author_sort Cheng, Qin
collection PubMed
description Malaria rapid diagnostic tests (RDTs) play a critical role in malaria case management, surveillance and case investigations. Test performance is largely determined by design and quality characteristics, such as detection sensitivity, specificity, and thermal stability. However, parasite characteristics such as variable or absent expression of antigens targeted by RDTs can also affect RDT performance. Plasmodium falciparum parasites lacking the PfHRP2 protein, the most common target antigen for detection of P. falciparum, have been reported in some regions. Therefore, accurately mapping the presence and prevalence of P. falciparum parasites lacking pfhrp2 would be an important step so that RDTs targeting alternative antigens, or microscopy, can be preferentially selected for use in such regions. Herein the available evidence and molecular basis for identifying malaria parasites lacking PfHRP2 is reviewed, and a set of recommended procedures to apply for future investigations for parasites lacking PfHRP2, is proposed.
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spelling pubmed-41154712014-07-31 Plasmodium falciparum parasites lacking histidine-rich protein 2 and 3: a review and recommendations for accurate reporting Cheng, Qin Gatton, Michelle L Barnwell, John Chiodini, Peter McCarthy, James Bell, David Cunningham, Jane Malar J Review Malaria rapid diagnostic tests (RDTs) play a critical role in malaria case management, surveillance and case investigations. Test performance is largely determined by design and quality characteristics, such as detection sensitivity, specificity, and thermal stability. However, parasite characteristics such as variable or absent expression of antigens targeted by RDTs can also affect RDT performance. Plasmodium falciparum parasites lacking the PfHRP2 protein, the most common target antigen for detection of P. falciparum, have been reported in some regions. Therefore, accurately mapping the presence and prevalence of P. falciparum parasites lacking pfhrp2 would be an important step so that RDTs targeting alternative antigens, or microscopy, can be preferentially selected for use in such regions. Herein the available evidence and molecular basis for identifying malaria parasites lacking PfHRP2 is reviewed, and a set of recommended procedures to apply for future investigations for parasites lacking PfHRP2, is proposed. BioMed Central 2014-07-22 /pmc/articles/PMC4115471/ /pubmed/25052298 http://dx.doi.org/10.1186/1475-2875-13-283 Text en Copyright © 2014 Cheng et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Cheng, Qin
Gatton, Michelle L
Barnwell, John
Chiodini, Peter
McCarthy, James
Bell, David
Cunningham, Jane
Plasmodium falciparum parasites lacking histidine-rich protein 2 and 3: a review and recommendations for accurate reporting
title Plasmodium falciparum parasites lacking histidine-rich protein 2 and 3: a review and recommendations for accurate reporting
title_full Plasmodium falciparum parasites lacking histidine-rich protein 2 and 3: a review and recommendations for accurate reporting
title_fullStr Plasmodium falciparum parasites lacking histidine-rich protein 2 and 3: a review and recommendations for accurate reporting
title_full_unstemmed Plasmodium falciparum parasites lacking histidine-rich protein 2 and 3: a review and recommendations for accurate reporting
title_short Plasmodium falciparum parasites lacking histidine-rich protein 2 and 3: a review and recommendations for accurate reporting
title_sort plasmodium falciparum parasites lacking histidine-rich protein 2 and 3: a review and recommendations for accurate reporting
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115471/
https://www.ncbi.nlm.nih.gov/pubmed/25052298
http://dx.doi.org/10.1186/1475-2875-13-283
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