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Discrete conformations of epitope II on the hepatitis C virus E2 protein for antibody-mediated neutralization and nonneutralization

The X-ray crystal structure of epitope II on the E2 protein of hepatitis C virus, in complex with nonneutralizing antibody mAb#12, has been solved at 2.90-Å resolution. The spatial arrangement of the essential components of epitope II (ie, the C-terminal α-helix and the N-terminal loop) was found to...

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Detalles Bibliográficos
Autores principales:	Deng, Lu, Ma, Li, Virata, Maria Luisa, Zhong, Lilin, Yan, Hailing, Zhao, Zhong, Struble, Evi, Feinstone, Stephen, Alter, Harvey, Zhang, Pei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2014
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115556/ https://www.ncbi.nlm.nih.gov/pubmed/25002515 http://dx.doi.org/10.1073/pnas.1411317111

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