Cargando…

A comprehensive assessment of resting state networks: bidirectional modification of functional integrity in cerebro-cerebellar networks in dementia

In resting state fMRI (rs-fMRI), only functional connectivity (FC) reductions in the default mode network (DMN) are normally reported as a biomarker for Alzheimer's disease (AD). In this investigation we have developed a comprehensive strategy to characterize the FC changes occurring in multipl...

Descripción completa

Detalles Bibliográficos
Autores principales: Castellazzi, Gloria, Palesi, Fulvia, Casali, Stefano, Vitali, Paolo, Sinforiani, Elena, Wheeler-Kingshott, Claudia A. M., D'Angelo, Egidio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115623/
https://www.ncbi.nlm.nih.gov/pubmed/25126054
http://dx.doi.org/10.3389/fnins.2014.00223
_version_ 1782328559317024768
author Castellazzi, Gloria
Palesi, Fulvia
Casali, Stefano
Vitali, Paolo
Sinforiani, Elena
Wheeler-Kingshott, Claudia A. M.
D'Angelo, Egidio
author_facet Castellazzi, Gloria
Palesi, Fulvia
Casali, Stefano
Vitali, Paolo
Sinforiani, Elena
Wheeler-Kingshott, Claudia A. M.
D'Angelo, Egidio
author_sort Castellazzi, Gloria
collection PubMed
description In resting state fMRI (rs-fMRI), only functional connectivity (FC) reductions in the default mode network (DMN) are normally reported as a biomarker for Alzheimer's disease (AD). In this investigation we have developed a comprehensive strategy to characterize the FC changes occurring in multiple networks and applied it in a pilot study of subjects with AD and Mild Cognitive Impairment (MCI), compared to healthy controls (HC). Resting state networks (RSNs) were studied in 14 AD (70 ± 6 years), 12 MCI (74 ± 6 years), and 16 HC (69 ± 5 years). RSN alterations were present in almost all the 15 recognized RSNs; overall, 474 voxels presented a reduced FC in MCI and 1244 in AD while 1627 voxels showed an increased FC in MCI and 1711 in AD. The RSNs were then ranked according to the magnitude and extension of FC changes (gFC), putting in evidence 6 RSNs with prominent changes: DMN, frontal cortical network (FCN), lateral visual network (LVN), basal ganglia network (BGN), cerebellar network (CBLN), and the anterior insula network (AIN). Nodes, or hubs, showing alterations common to more than one RSN were mostly localized within the prefrontal cortex and the mesial-temporal cortex. The cerebellum showed a unique behavior where voxels of decreased gFC were only found in AD while a significant gFC increase was only found in MCI. The gFC alterations showed strong correlations (p < 0.001) with psychological scores, in particular Mini-Mental State Examination (MMSE) and attention/memory tasks. In conclusion, this analysis revealed that the DMN was affected by remarkable FC increases, that FC alterations extended over several RSNs, that derangement of functional relationships between multiple areas occurred already in the early stages of dementia. These results warrant future work to verify whether these represent compensatory mechanisms that exploit a pre-existing neural reserve through plasticity, which evolve in a state of lack of connectivity between different networks with the worsening of the pathology.
format Online
Article
Text
id pubmed-4115623
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-41156232014-08-14 A comprehensive assessment of resting state networks: bidirectional modification of functional integrity in cerebro-cerebellar networks in dementia Castellazzi, Gloria Palesi, Fulvia Casali, Stefano Vitali, Paolo Sinforiani, Elena Wheeler-Kingshott, Claudia A. M. D'Angelo, Egidio Front Neurosci Neuroscience In resting state fMRI (rs-fMRI), only functional connectivity (FC) reductions in the default mode network (DMN) are normally reported as a biomarker for Alzheimer's disease (AD). In this investigation we have developed a comprehensive strategy to characterize the FC changes occurring in multiple networks and applied it in a pilot study of subjects with AD and Mild Cognitive Impairment (MCI), compared to healthy controls (HC). Resting state networks (RSNs) were studied in 14 AD (70 ± 6 years), 12 MCI (74 ± 6 years), and 16 HC (69 ± 5 years). RSN alterations were present in almost all the 15 recognized RSNs; overall, 474 voxels presented a reduced FC in MCI and 1244 in AD while 1627 voxels showed an increased FC in MCI and 1711 in AD. The RSNs were then ranked according to the magnitude and extension of FC changes (gFC), putting in evidence 6 RSNs with prominent changes: DMN, frontal cortical network (FCN), lateral visual network (LVN), basal ganglia network (BGN), cerebellar network (CBLN), and the anterior insula network (AIN). Nodes, or hubs, showing alterations common to more than one RSN were mostly localized within the prefrontal cortex and the mesial-temporal cortex. The cerebellum showed a unique behavior where voxels of decreased gFC were only found in AD while a significant gFC increase was only found in MCI. The gFC alterations showed strong correlations (p < 0.001) with psychological scores, in particular Mini-Mental State Examination (MMSE) and attention/memory tasks. In conclusion, this analysis revealed that the DMN was affected by remarkable FC increases, that FC alterations extended over several RSNs, that derangement of functional relationships between multiple areas occurred already in the early stages of dementia. These results warrant future work to verify whether these represent compensatory mechanisms that exploit a pre-existing neural reserve through plasticity, which evolve in a state of lack of connectivity between different networks with the worsening of the pathology. Frontiers Media S.A. 2014-07-30 /pmc/articles/PMC4115623/ /pubmed/25126054 http://dx.doi.org/10.3389/fnins.2014.00223 Text en Copyright © 2014 Castellazzi, Palesi, Casali, Vitali, Sinforiani, Wheeler-Kingshott and D'Angelo. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Castellazzi, Gloria
Palesi, Fulvia
Casali, Stefano
Vitali, Paolo
Sinforiani, Elena
Wheeler-Kingshott, Claudia A. M.
D'Angelo, Egidio
A comprehensive assessment of resting state networks: bidirectional modification of functional integrity in cerebro-cerebellar networks in dementia
title A comprehensive assessment of resting state networks: bidirectional modification of functional integrity in cerebro-cerebellar networks in dementia
title_full A comprehensive assessment of resting state networks: bidirectional modification of functional integrity in cerebro-cerebellar networks in dementia
title_fullStr A comprehensive assessment of resting state networks: bidirectional modification of functional integrity in cerebro-cerebellar networks in dementia
title_full_unstemmed A comprehensive assessment of resting state networks: bidirectional modification of functional integrity in cerebro-cerebellar networks in dementia
title_short A comprehensive assessment of resting state networks: bidirectional modification of functional integrity in cerebro-cerebellar networks in dementia
title_sort comprehensive assessment of resting state networks: bidirectional modification of functional integrity in cerebro-cerebellar networks in dementia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115623/
https://www.ncbi.nlm.nih.gov/pubmed/25126054
http://dx.doi.org/10.3389/fnins.2014.00223
work_keys_str_mv AT castellazzigloria acomprehensiveassessmentofrestingstatenetworksbidirectionalmodificationoffunctionalintegrityincerebrocerebellarnetworksindementia
AT palesifulvia acomprehensiveassessmentofrestingstatenetworksbidirectionalmodificationoffunctionalintegrityincerebrocerebellarnetworksindementia
AT casalistefano acomprehensiveassessmentofrestingstatenetworksbidirectionalmodificationoffunctionalintegrityincerebrocerebellarnetworksindementia
AT vitalipaolo acomprehensiveassessmentofrestingstatenetworksbidirectionalmodificationoffunctionalintegrityincerebrocerebellarnetworksindementia
AT sinforianielena acomprehensiveassessmentofrestingstatenetworksbidirectionalmodificationoffunctionalintegrityincerebrocerebellarnetworksindementia
AT wheelerkingshottclaudiaam acomprehensiveassessmentofrestingstatenetworksbidirectionalmodificationoffunctionalintegrityincerebrocerebellarnetworksindementia
AT dangeloegidio acomprehensiveassessmentofrestingstatenetworksbidirectionalmodificationoffunctionalintegrityincerebrocerebellarnetworksindementia
AT castellazzigloria comprehensiveassessmentofrestingstatenetworksbidirectionalmodificationoffunctionalintegrityincerebrocerebellarnetworksindementia
AT palesifulvia comprehensiveassessmentofrestingstatenetworksbidirectionalmodificationoffunctionalintegrityincerebrocerebellarnetworksindementia
AT casalistefano comprehensiveassessmentofrestingstatenetworksbidirectionalmodificationoffunctionalintegrityincerebrocerebellarnetworksindementia
AT vitalipaolo comprehensiveassessmentofrestingstatenetworksbidirectionalmodificationoffunctionalintegrityincerebrocerebellarnetworksindementia
AT sinforianielena comprehensiveassessmentofrestingstatenetworksbidirectionalmodificationoffunctionalintegrityincerebrocerebellarnetworksindementia
AT wheelerkingshottclaudiaam comprehensiveassessmentofrestingstatenetworksbidirectionalmodificationoffunctionalintegrityincerebrocerebellarnetworksindementia
AT dangeloegidio comprehensiveassessmentofrestingstatenetworksbidirectionalmodificationoffunctionalintegrityincerebrocerebellarnetworksindementia