Cargando…
Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease
The greatest risk factor for Alzheimer's disease (AD) is age, and changes in the ageing nervous system are likely contributors to AD pathology. Amyloid beta (Aβ) accumulation, which occurs as a result of the amyloidogenic processing of amyloid precursor protein (APP), is thought to initiate the...
Autores principales: | Sofola-Adesakin, Oyinkan, Castillo-Quan, Jorge I., Rallis, Charalampos, Tain, Luke S., Bjedov, Ivana, Rogers, Iain, Li, Li, Martinez, Pedro, Khericha, Mobina, Cabecinha, Melissa, Bähler, Jürg, Partridge, Linda |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115666/ https://www.ncbi.nlm.nih.gov/pubmed/25126078 http://dx.doi.org/10.3389/fnagi.2014.00190 |
Ejemplares similares
-
Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models
por: Kerr, Fiona, et al.
Publicado: (2018) -
pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicity
por: Sofola-Adesakin, Oyinkan, et al.
Publicado: (2016) -
Inhibition of TORC1 signaling and increased lifespan: gained in translation?
por: Rallis, Charalampos, et al.
Publicado: (2013) -
Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease
por: Kerr, Fiona, et al.
Publicado: (2017) -
The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation
por: Bjedov, Ivana, et al.
Publicado: (2020)