Successful wheat-specific oral immunotherapy in highly sensitive individuals with a novel multirush/maintenance regimen

We reported a successful oral immunotherapy (OIT) in 2 children with high wheat sensitivity (4 and 14 years old boys). Oral challenges indicated eliciting doses of 300 mg, and wheat flour of 30 mg. The OIT protocol includes 5 days of build-up phase in the hospital, intervening with 2 to 5 months of...

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Detalles Bibliográficos
Autores principales: Pacharn, Punchama, Siripipattanamongkol, Nunthana, Veskitkul, Jittima, Jirapongsananuruk, Orathai, Visitsunthorn, Nualanong, Vichyanond, Pakit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116039/
https://www.ncbi.nlm.nih.gov/pubmed/25097855
http://dx.doi.org/10.5415/apallergy.2014.4.3.180
Descripción
Sumario:We reported a successful oral immunotherapy (OIT) in 2 children with high wheat sensitivity (4 and 14 years old boys). Oral challenges indicated eliciting doses of 300 mg, and wheat flour of 30 mg. The OIT protocol includes 5 days of build-up phase in the hospital, intervening with 2 to 5 months of home maintenance phase. Patients could tolerate 45 g, and 60 g of wheat flour per day, respectively. We have demonstrated that OIT to a large amount of wheat in extremely sensitized patients could be achieved with a stepwise multi oral/maintenance regimen.

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