Successful wheat-specific oral immunotherapy in highly sensitive individuals with a novel multirush/maintenance regimen

We reported a successful oral immunotherapy (OIT) in 2 children with high wheat sensitivity (4 and 14 years old boys). Oral challenges indicated eliciting doses of 300 mg, and wheat flour of 30 mg. The OIT protocol includes 5 days of build-up phase in the hospital, intervening with 2 to 5 months of...

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Autores principales: Pacharn, Punchama, Siripipattanamongkol, Nunthana, Veskitkul, Jittima, Jirapongsananuruk, Orathai, Visitsunthorn, Nualanong, Vichyanond, Pakit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116039/
https://www.ncbi.nlm.nih.gov/pubmed/25097855
http://dx.doi.org/10.5415/apallergy.2014.4.3.180
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author Pacharn, Punchama
Siripipattanamongkol, Nunthana
Veskitkul, Jittima
Jirapongsananuruk, Orathai
Visitsunthorn, Nualanong
Vichyanond, Pakit
author_facet Pacharn, Punchama
Siripipattanamongkol, Nunthana
Veskitkul, Jittima
Jirapongsananuruk, Orathai
Visitsunthorn, Nualanong
Vichyanond, Pakit
author_sort Pacharn, Punchama
collection PubMed
description We reported a successful oral immunotherapy (OIT) in 2 children with high wheat sensitivity (4 and 14 years old boys). Oral challenges indicated eliciting doses of 300 mg, and wheat flour of 30 mg. The OIT protocol includes 5 days of build-up phase in the hospital, intervening with 2 to 5 months of home maintenance phase. Patients could tolerate 45 g, and 60 g of wheat flour per day, respectively. We have demonstrated that OIT to a large amount of wheat in extremely sensitized patients could be achieved with a stepwise multi oral/maintenance regimen.
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spelling pubmed-41160392014-08-05 Successful wheat-specific oral immunotherapy in highly sensitive individuals with a novel multirush/maintenance regimen Pacharn, Punchama Siripipattanamongkol, Nunthana Veskitkul, Jittima Jirapongsananuruk, Orathai Visitsunthorn, Nualanong Vichyanond, Pakit Asia Pac Allergy Case Report We reported a successful oral immunotherapy (OIT) in 2 children with high wheat sensitivity (4 and 14 years old boys). Oral challenges indicated eliciting doses of 300 mg, and wheat flour of 30 mg. The OIT protocol includes 5 days of build-up phase in the hospital, intervening with 2 to 5 months of home maintenance phase. Patients could tolerate 45 g, and 60 g of wheat flour per day, respectively. We have demonstrated that OIT to a large amount of wheat in extremely sensitized patients could be achieved with a stepwise multi oral/maintenance regimen. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2014-07 2014-07-29 /pmc/articles/PMC4116039/ /pubmed/25097855 http://dx.doi.org/10.5415/apallergy.2014.4.3.180 Text en Copyright © 2014. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Pacharn, Punchama
Siripipattanamongkol, Nunthana
Veskitkul, Jittima
Jirapongsananuruk, Orathai
Visitsunthorn, Nualanong
Vichyanond, Pakit
Successful wheat-specific oral immunotherapy in highly sensitive individuals with a novel multirush/maintenance regimen
title Successful wheat-specific oral immunotherapy in highly sensitive individuals with a novel multirush/maintenance regimen
title_full Successful wheat-specific oral immunotherapy in highly sensitive individuals with a novel multirush/maintenance regimen
title_fullStr Successful wheat-specific oral immunotherapy in highly sensitive individuals with a novel multirush/maintenance regimen
title_full_unstemmed Successful wheat-specific oral immunotherapy in highly sensitive individuals with a novel multirush/maintenance regimen
title_short Successful wheat-specific oral immunotherapy in highly sensitive individuals with a novel multirush/maintenance regimen
title_sort successful wheat-specific oral immunotherapy in highly sensitive individuals with a novel multirush/maintenance regimen
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116039/
https://www.ncbi.nlm.nih.gov/pubmed/25097855
http://dx.doi.org/10.5415/apallergy.2014.4.3.180
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