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Pre-Hospital Risk Factors for Inpatient Death from Severe Febrile Illness in Malian Children
BACKGROUND: Inpatient case fatality from severe malaria remains high in much of sub-Saharan Africa. The majority of these deaths occur within 24 hours of admission, suggesting that pre-hospital management may have an impact on the risk of case fatality. METHODS: Prospective cohort study, including q...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116122/ https://www.ncbi.nlm.nih.gov/pubmed/25075623 http://dx.doi.org/10.1371/journal.pone.0102530 |
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author | Willcox, Merlin L. Dicko, Moussa I. Graz, Bertrand Forster, Mathieu Shinkins, Bethany Diakite, Chiaka Giani, Sergio Falquet, Jacques Diallo, Drissa Dembélé, Eugène |
author_facet | Willcox, Merlin L. Dicko, Moussa I. Graz, Bertrand Forster, Mathieu Shinkins, Bethany Diakite, Chiaka Giani, Sergio Falquet, Jacques Diallo, Drissa Dembélé, Eugène |
author_sort | Willcox, Merlin L. |
collection | PubMed |
description | BACKGROUND: Inpatient case fatality from severe malaria remains high in much of sub-Saharan Africa. The majority of these deaths occur within 24 hours of admission, suggesting that pre-hospital management may have an impact on the risk of case fatality. METHODS: Prospective cohort study, including questionnaire about pre-hospital treatment, of all 437 patients admitted with severe febrile illness (presumed to be severe malaria) to the paediatric ward in Sikasso Regional Hospital, Mali, in a two-month period. FINDINGS: The case fatality rate was 17.4%. Coma, hypoglycaemia and respiratory distress at admission were associated with significantly higher mortality. In multiple logistic regression models and in a survival analysis to examine pre-admission risk factors for case fatality, the only consistent and significant risk factor was sex. Girls were twice as likely to die as boys (AOR 2.00, 95% CI 1.08–3.70). There was a wide variety of pre-hospital treatments used, both modern and traditional. None had a consistent impact on the risk of death across different analyses. Reported use of traditional treatments was not associated with post-admission outcome. INTERPRETATION: Aside from well-recognised markers of severity, the main risk factor for death in this study was female sex, but this study cannot determine the reason why. Differences in pre-hospital treatments were not associated with case fatality. |
format | Online Article Text |
id | pubmed-4116122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41161222014-08-04 Pre-Hospital Risk Factors for Inpatient Death from Severe Febrile Illness in Malian Children Willcox, Merlin L. Dicko, Moussa I. Graz, Bertrand Forster, Mathieu Shinkins, Bethany Diakite, Chiaka Giani, Sergio Falquet, Jacques Diallo, Drissa Dembélé, Eugène PLoS One Research Article BACKGROUND: Inpatient case fatality from severe malaria remains high in much of sub-Saharan Africa. The majority of these deaths occur within 24 hours of admission, suggesting that pre-hospital management may have an impact on the risk of case fatality. METHODS: Prospective cohort study, including questionnaire about pre-hospital treatment, of all 437 patients admitted with severe febrile illness (presumed to be severe malaria) to the paediatric ward in Sikasso Regional Hospital, Mali, in a two-month period. FINDINGS: The case fatality rate was 17.4%. Coma, hypoglycaemia and respiratory distress at admission were associated with significantly higher mortality. In multiple logistic regression models and in a survival analysis to examine pre-admission risk factors for case fatality, the only consistent and significant risk factor was sex. Girls were twice as likely to die as boys (AOR 2.00, 95% CI 1.08–3.70). There was a wide variety of pre-hospital treatments used, both modern and traditional. None had a consistent impact on the risk of death across different analyses. Reported use of traditional treatments was not associated with post-admission outcome. INTERPRETATION: Aside from well-recognised markers of severity, the main risk factor for death in this study was female sex, but this study cannot determine the reason why. Differences in pre-hospital treatments were not associated with case fatality. Public Library of Science 2014-07-30 /pmc/articles/PMC4116122/ /pubmed/25075623 http://dx.doi.org/10.1371/journal.pone.0102530 Text en © 2014 Willcox et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Willcox, Merlin L. Dicko, Moussa I. Graz, Bertrand Forster, Mathieu Shinkins, Bethany Diakite, Chiaka Giani, Sergio Falquet, Jacques Diallo, Drissa Dembélé, Eugène Pre-Hospital Risk Factors for Inpatient Death from Severe Febrile Illness in Malian Children |
title | Pre-Hospital Risk Factors for Inpatient Death from Severe Febrile Illness in Malian Children |
title_full | Pre-Hospital Risk Factors for Inpatient Death from Severe Febrile Illness in Malian Children |
title_fullStr | Pre-Hospital Risk Factors for Inpatient Death from Severe Febrile Illness in Malian Children |
title_full_unstemmed | Pre-Hospital Risk Factors for Inpatient Death from Severe Febrile Illness in Malian Children |
title_short | Pre-Hospital Risk Factors for Inpatient Death from Severe Febrile Illness in Malian Children |
title_sort | pre-hospital risk factors for inpatient death from severe febrile illness in malian children |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116122/ https://www.ncbi.nlm.nih.gov/pubmed/25075623 http://dx.doi.org/10.1371/journal.pone.0102530 |
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